Brenig Therapeutics has raised $65 million to advance its lead candidate, LRRK inhibitor BT-267, into human clinical trials as a possible treatment for idiopathic (of unknown cause) and LRRK2-associated Parkinson’s disease. The funds will be used to test BT-267 in healthy volunteers in a first-in-human study, Brenig said.
Home-based exercise, such as aerobic, strength, or balance exercises, helps relieve overall motor symptoms of Parkinson’s disease, according to a meta-analysis. But benefits were only seen when patients exercised for a minimum of eight weeks, and no less than 30 times. The findings provide “clinicians and patients with clear…
The Michael J. Fox Foundation for Parkinson’s Research (MJFF) has awarded a $6 million grant to Lario Therapeutics to advance early studies into CaV2.3 calcium channel inhibitors as a potential disease-modifying therapy for Parkinson’s disease. Lario’s preclinical program is being developed in collaboration with the Oxford…
GUCY2C — a protein found mainly in the gut, but also in the brain — appears to be produced in greater amounts in Parkinson’s disease as a mechanism to protect nerve cells from damage and toxic insults, a preclinical study found. While the findings come from mice, they put…
Clumps of alpha-synuclein, the protein responsible for nerve cell death in Parkinson’s disease, initially form under medium salt conditions. However, over time, these clumps, or aggregates, transform into droplets through a process called liquid-liquid phase separation (LLPS), effectively preventing further clumping, or aggregation, of alpha-synuclein, a study has shown.
Scientists have discovered a link between a mutation in the CARS gene and late-onset neurological disorders with symptoms, such as movement disorder, similar to those seen in Parkinson’s disease patients. The mutation, known as CARS E795V, was identified as the cause of a neurological condition affecting nine people…
A model that uses artificial intelligence (AI) to analyze electroencephalography (EEG)-based patterns of brain activity showed a potential to accurately diagnose Parkinson’s disease at early stages, according to a recent study from Australia. EEG, a non-invasive way of studying the brain’s electrical activity, is used to detect patterns of…
A new collaboration dubbed the Accelerating Medicines Partnership in Parkinson’s Disease and Related Disorders, or simply AMP PDRD, will work to identify specific biomarkers that can differentiate Parkinson’s from other neurodegenerative disorders with similar symptoms. The goal, according to the Foundation…
Measuring levels of lipids (fat molecules) in the blood may help predict the severity of symptoms in Parkinson’s disease, a new study suggests. The study, “Prediction of motor and non-motor Parkinson’s disease symptoms using serum lipidomics and machine learning: a 2-year study,” was published in npj…
Four endurance athletes, one of whom has Parkinson’s disease, have embarked on a 2,800-mile rowing journey across the Pacific Ocean this summer. The team’s goal is to raise $28 million for Parkinson’s research through The Michael J. Fox Foundation for Parkinson’s Research(MJFF). The “Team Human Powered Potential” aims…
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