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If the FDA approves Sunovion’s APL-130277 come January, Parkinson’s patients will have a first oral treatment — and a first new treatment in more than a decade — for off episodes, those times of difficulties with movement despite taking treatments that stimulate dopamine receptors, like levodopa. “We think that…

People with inflammatory bowel disease (IBD), an umbrella name for disorders marked by prolonged inflammation of the digestive tract, are at a higher-than-usual risk for Parkinson’s disease, a review study involving 8.9 million IBD patients suggests. The study, “The risk of Parkinson’s disease in inflammatory bowel disease: A…

In 2017, the United Kingdom’s National Institute for Health and Care Excellence (NICE) published its latest guidelines on how adult patients and their caregivers should manage Parkinson’s disease (PD). In a new commentary, four experts discuss the implications of some of these recommendations for both patients and healthcare professionals,…

A newly identified small molecule compound, called SynuClean-D, can prevent the formation of toxic alpha-synuclein aggregates, disrupt the propagation of amyloid fibrils, and rescue nerve cells from alpha-synuclein-induced death in an animal model of Parkinson’s disease, a study shows. Given this particular activity, SynuClean-D may be a promising candidate…

Parkinson’s researchers need to focus on human cells and tissues, implement modern computer modeling approaches, and shift away from animal models, according to a recent study. Earlier transition from preclinical studies to clinical trials also could be beneficial, the study authors suggest. The study, “Parkinson’s disease…