Researchers have discovered a new enzyme that might aid in “putting the brakes” on Parkinson’s by inhibiting the LRRK2 pathway, known to play a critical role in this neurodegenerative disease. The findings are still at an early stage, but the team is already trying to find compounds that can…
Researchers have developed a computer model of the mouse brain that integrates both Parkinson’s disease-related genetic risk factors and the animals’ brain networks to help them understand how abnormal alpha-synuclein protein spreads and how neurodegeneration progresses. The study, “Spread of α-synuclein pathology through the brain connectome is modulated by…
The impact of climate change and environmental risk factors on brain health was spotlighted at this year’s World Congress of Neurology, a gathering of scientists and clinicians to discuss the latest advances and future developments in neurology. The recent XXIV World Congress of Neurology in Dubai, United Arab Emirates,…
Researchers have developed algorithms that work with wearable sensors to continuously monitor tremor, and estimate total tremor, in Parkinson’s patients as they go about their daily routines. Analyses of sensor results using one algorithm, in particular, were similar to an established test assessing tremor without being dependent on the time the…
A particular signaling protein in the brain, called melanin-concentrating hormone (MCH), was seen to help regulate impulse control in rats, a study reports. This finding may have implications for disorders where impulse behaviors manifest, from binge eating and drug addiction to Parkinson’s disease. The study, “Hypothalamus-hippocampus circuitry…
The U.S. Defense Department has awarded researchers from Northeast Ohio Medical University (NOMU) and Michigan State University (MSU) about $1 million each to study the effect of exercise at different stages of Parkinson’s disease. The three-year grant went to longtime collaborators Sheila Fleming, PhD,…
Inhibiting the activity of LRRK2 kinase — an enzyme whose mutated form is one of the most common genetic causes of Parkinson’s disease — may benefit patients both with and without this disease-related mutation, a study finds. Molecules that block the activity of the LRRK2 kinase —…
The way the brain of a Parkinson’s disease patient is wired may help doctors predict if he or she will develop impulse control disorders following dopamine replacement therapy, a study finds. The results, “The structural connectivity of discrete networks underlies impulsivity and gambling in Parkinson’s disease,”…
Both power and strength training can improve muscle performance in people with Parkinson’s disease, but these improvements may not translate to functional movement, a new study has found. The study, titled “Power vs strength training to improve muscular strength, power, balance and functional movement in individuals diagnosed…
Fesoterodine fumarate, the active compound of a medication for overactive bladder, can help reduce urinary symptoms in Parkinson’s disease patients, a clinical study has found. The findings, “Randomized, controlled trial of fesoterodine fumarate for overactive bladder in Parkinson’s disease” were published in the World Journal of…
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