Using a light-activated protein to improve the function of mitochondria — cells’ powerhouses— could be a therapeutic strategy for Parkinson’s disease (PD), a new study done in flies suggests. The results of the study, “Light-driven activation of mitochondrial proton-motive force improves motor behaviors in a…
Cure Parkinson’s Trust (CPT) and the Van Andel Institute (VAI) will contribute $4.5 million in total to support a global program that seeks to develop disease-modifying Parkinson’s therapies. The three-year funding agreement backs the international Linked Clinical Trials (LCT) initiative, established by the two organizations in 2012…
Increasing evidence links insulin-like growth factor 1 (IGF-1) deficiency to the development and progression of Parkinson’s disease, a review study said. Estrogen, the female sex hormone thought to hold potential beneficial effects against Parkinson’s, or PD, may exert its protective actions via IGF-1, the researchers said.
Memory-related mild cognitive impairment in Parkinson’s disease may be associated with a more severe buildup of alpha-synuclein protein in the brain — such as that observed in more advanced stages of the disease, a study finds. The results of the study, “Neuropathological Findings in Parkinson’s Disease With…
People with Parkinson’s disease reported a need for increased planning in their lives due to limited mobility and restrictions in everyday life caused by a decrease in their balance control, a study shows. Study participants described using specific movement and cognitive strategies as a consequence of…
Palliative care — focusing on physical, psychosocial and spiritual treatment — for people with Parkinson’s disease and related disorders (PDRD) led to a significantly better quality of life (QoL) than standard care alone, a study finds. Easing of both non-motor and motor symptom…
Activated immune T-cells can infiltrate the brain and promote neurodegeneration in non-human primate models of Parkinson’s during the chronic stages of the disease, a study has found. Results of the study, “Chronic infiltration of T lymphocytes into the brain in a non-human primate model of Parkinson’s disease,”…
Genetic variations in the gene apolipoprotein E (APOE) alter the dynamics of alpha-synuclein protein buildup in the brains of mice with Parkinson’s disease (PD), according to a new study. This suggests suggests that alterations in APOE could affect the occurrence of dementia in humans with the neurodegenerative…
The U.S. Food and Drug Administration (FDA) has granted breakthrough device designation to nQ Medical’s neuroQUERTY software, which is designed to monitor brain health and Parkinson’s disease progression. Breakthrough device status is given to medical devices that have the potential to be an effective treatment or…
Assessing the shape of alpha-synuclein aggregates in the brain helps to distinguish between Parkinson’s disease (PD) and another progressive neurodegenerative disorder known as multiple system atrophy (MSA), a study suggests. The study, “Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy,” was published in Nature. Parkinson’s…
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