News

Breathing carbon dioxide (CO2) for brief periods may help activate the brain’s natural cleanup systems that remove toxic proteins in people with Parkinson’s disease, according to a new study. Researchers stressed that more work is needed to confirm the results and evaluate the clinical relevance of this approach, but…

A smartphone app allowing Parkinson’s disease patients to report their day-to-day symptoms is a reliable tool for improving communication with doctors, a study found. Patients’ self-assessments using the Parkinson’s Image Self Report generally aligned with doctors’ clinical ratings, the researchers said. “Integration with wearables and telemedicine may advance patient-centered [Parkinson’s]…

Spinal cord stimulation appears to be safe and may help people with Parkinson’s disease maintain movement, although it did not improve posture, balance, or gait compared with sham treatment in a small study from Denmark. The STEP-PD study (NCT05110053) involved 12 patients with gait impairments who were randomly…

Targeting a brain network that links thinking and movement may be an effective treatment strategy for easing motor symptoms in people with Parkinson’s disease. The somato-cognitive action network (SCAN) lies within the motor cortex, a brain region that controls body movements. In Parkinson’s, SCAN dysfunction, particularly increased connectivity between…

The University of Southern California’s Keck School of Medicine is recruiting patients for a Phase 1 clinical trial evaluating RNDP-001, an experimental cell replacement therapy being developed by Kenai Therapeutics for moderate to severe Parkinson’s disease. The company-sponsored REPLACE (NCT07106021), which began dosing late last year,…

Merz Therapeutics North America has launched “Celebrating the Fighters,” a nationwide U.S. community campaign honoring the resiliency and courage of people with Parkinson’s disease. The campaign features several initiatives, including a national TV ad, and offers social media and advocacy resources. It leverages the resilience and spirit of…

Parkinson’s disease may actually begin deep in the gut, where immune cells meant to protect the body inadvertently help toxic proteins make their way to the brain, according to a new study. Researchers at the UK Dementia Research Institute at University College London (UCL) have identified a specific type…

Small particles called exosomes may help deliver curcumin directly to dopamine-producing nerve cells damaged in Parkinson’s disease, a study in rats suggests. In laboratory and animal experiments, the targeted delivery helped protect these cells and was associated with improved outcomes, pointing to a potential precision-delivery strategy for future research.

Boston University has been awarded a $2 million research grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to support a clinical study examining motor and cognitive factors related to changes in walking among people with Parkinson’s disease who use MedRhythms’ music-based platform, MOVIVE. MOVIVE…

Researchers at Case Western Reserve University in Cleveland, Ohio, developed a new compound that blocks a harmful interaction between the alpha-synuclein protein and a mitochondrial enzyme called ClpP. In a mouse model of Parkinson’s disease, the treatment helped preserve dopamine-producing brain cells and improved movement and cognitive performance. The…