The use of non-steroidal anti-inflammatory drugs (NSAIDs) seems to have no effect on the incidence of Parkinson’s disease, according to a large retrospective Norwegian study. Researchers focused on the NSAIDs prescribed most in Norway: diclofenac, ibuprofen, and naproxen. In the study “NSAID use is not associated with Parkinson’s…
A potential Parkinson’s therapy based on a protein with an ability to protect neurons — called recombinant (lab-made) human cerebral dopamine neurotrophic factor (rhCDNF) — has been transformed into tiny nanoparticles that may allow for its use as a nasal spray, Herantis Pharma,…
An artificial intelligence (AI) tool was able to distinguish, with great accuracy, Parkinson’s patients from healthy peers by analyzing short videos of facial expressions, particularly smiles, a small study shows. The predictive accuracy of the new tool was comparable to that of video analysis that uses motor tasks to…
Two investigational small molecules known as GT-02287 and GT-02329 lowered toxic protein levels in patient-derived cell models of Parkinson’s disease associated with a mutation in GBA1, their developer, Gain Therapeutics, announced. Gain is planning additional preclinical studies this year that could support applications to regulatory agencies allowing the compounds to…
A new type of artificial intelligence (AI) algorithm, developed by the Mayo Clinic and the Google Research Brain Team, can potentially pave the way toward more directed brain stimulation for the treatment of Parkinson’s disease and other movement-related disorders. According to researchers, this algorithm can more accurately determine…
People with gait difficulties due to Parkinson’s disease make adjustments that aid in walking, but many are not aware of the variety of “compensation strategies” available to them, a study based on a patient survey reported. Some of these strategies may be more useful in certain situations or to a given…
Building upon previous efforts, Parkinson’s UK has opened a monthlong marketing campaign aiming for a better understanding of Parkinson’s disease — particularly among young adults — and of the daily challenges facing patients, caregivers, and family members. Specifically, the group wants to help people more deeply understand and care…
Researchers developed “mini-brains” — midbrain-like organoids — that recapitulate for a first time two key Parkinson’s hallmarks in that organ: the formation of toxic protein clumps known as Lewy bodies and the loss of dopamine-producing neurons. A combination of two known Parkinson’s risk factors — a deficiency of the beta-glucocerebrosidase…
A walking program seems to boost the benefits of respiratory muscle training — which consists of specific exercises designed to improve the function of muscles used in breathing — in people with Parkinson’s disease, a small study has found. In the study, patients who followed an eight-week walking program…
One in three people with early to mid-stage Parkinson’s disease were found to have difficulties in learning a new task by following instructions. The deficits were more prone during the early stages of learning, when new memories are being made, and were linked to poorer activation of certain brain…
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