An open-label extension study has been launched for NOPARK, a placebo-controlled Phase 2 clinical trial that’s assessing the effectiveness of nicotinamide riboside (NR) with Parkinson’s disease. NR is the active ingredient of Niagen, a dietary oral supplement that ChromaDex markets to promote “healthy aging.” Dietary supplements, unlike…
News
A family of proteins called Piwis and the tiny regulatory RNA molecules they interact with — Piwi-interacting RNA (piRNA) — are critical for the formation of new neurons in the adult brain, according to recent research in mice. Data showed that depletion of a specific Piwi protein, called Mili, in…
Eisai is collaborating with Washington University School of Medicine in St. Louis in research into new treatments for Parkinson’s disease and other neurodegenerative disorders. The Japan-based pharmaceutical company’s aim is to meld the expertise of Washington University’s investigators in basic and clinical research for such disorders with its…
Nearly 90,000 people, 65 or older, are diagnosed with Parkinson’s disease every year in the U.S., representing an increase of about 50% relative to previous estimates of the disease’s incidence, a study showed. “These updated estimates of incidence are necessary for understanding disease risk, planning health care delivery, and…
SLS-004, Seelos Therapeutics‘ investigational gene therapy for Parkinson’s disease, lowered alpha-synuclein levels and prevented the degeneration of dopamine-producing, or dopaminergic, neurons in a mouse model of the disease, the company announced. A hallmark of the neurodegenerative disease, the loss of dopaminergic neurons in a brain region called the…
Clinical Ink is partnering with a “leading biopharmaceutical organization” to monitor symptoms of people with Parkinson’s disease at home and clinical sites in the U.S. and Europe using the company’s technology. This will be part of a late-phase clinical development program, in which symptoms of Parkinson’s patients will…
Top-line results are expected next month from a Phase 2b clinical trial testing whether the investigational oral therapy mesdopetam can ease levodopa-induced dyskinesia, or involuntary movements, in people with Parkinson’s disease. IRLAB Therapeutics, the therapy’s original developer and sponsor of the trial, announced that the final participant…
Among people diagnosed with melanoma, a type of skin cancer, the tumor is twice as likely to be found along the head or neck if they also have Parkinson’s disease, a study found. These findings support the importance of screening these regions for more accurate melanoma surveillance in Parkinson’s…
Nitrase Therapeutics has partnered with HitGen in the search for novel therapies that suppress nitrases, a class of enzymes discovered by Nitrase. Nitrases are responsible for nitration, a type of biochemical modification of proteins that is linked to cellular stress and can change that protein’s structure, function, and…
Both type 2 diabetes and prediabetes — a condition in which blood sugar levels are abnormally high, but not high enough to constitute diabetes — are significantly associated with poorer cognition in people with Parkinson’s disease, according to a small study from South Korea. These findings add to previous…
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