Treatment with DopaFuse, a continuous oral levodopa-carbidopa delivery system being developed by SynAgile, was safe and lessened motor complications in people with Parkinson’s disease, according to results from a Phase 2 clinical trial. “These results suggest that the DopaFuse [levodopa-carbidopa] delivery system can provide a safe, non-invasive…
A gene therapy designed to track down and keep overactive brain cells in check was able to lower the number of seizures in a mouse study of epilepsy. This therapy is also notable in sparing healthy brain tissue by switching itself off after its work is done. Should early work…
A specific mutation in the LRRK2 gene — whose variants are often associated with Parkinson’s disease – renders immune cells called macrophages more susceptible to death after infection, according to new research that the scientists say gets back to basics. The team say this genetic variant, known as the…
Dental care often is irregular in people with Parkinson’s disease, who also require more dental treatments that those without this disease, a study from Denmark reported. High-quality initiatives addressing basic care, from daily oral cleanings to regular checkups that could reduce cavities and tooth extractions, are needed for better…
People who had COVID-19 might have an increased risk for developing neurodegenerative diseases, such as Parkinson’s disease, researchers in Australia found. Moreover, the researchers have offered a possible treatment to reduce the  COVID-induced neuroinflammation. COVID-19 activates an inflammatory response in the brain that is similar to Parkinson’s disease, contributing…
A new machine-learning algorithm — a type of artificial intelligence or AI — that integrates facial expression and voice recordings using just a smartphone camera could help clinicians in the early detection of Parkinson’s disease, a study has found. Combining data on changes in voice and facial features with…
In recognition of scientist Timothy Greenamyre’s pioneering work in Parkinson’s disease, The Michael J. Fox Foundation (MJFF) for Parkinson’s Research has awarded him the 2022 Robert A. Pritzker Prize. Greenamyre, MD, PhD, is a professor and vice chair of neurology at the University of Pittsburgh, where he serves…
Neural implants combining artificial intelligence with microelectronics could directly modulate the brain’s activity to help treat brain disorders, including Parkinson’s disease. “Neurons talk to each other in part via electrical signals, and a therapeutic neural implant produces electrical stimulation – like a pacemaker for the brain. In cases of…
Add-on treatment with a low dose of zonisamide, an anti-seizure medication, failed to significantly ease tremor in a pilot study of people with a tremor-dominant form of Parkinson’s disease. However, when researchers preformed their analysis and included all people —  even those who dropped out of the study…
New York University Langone Health is collaborating with the Michael J. Fox Foundation for Parkinson’s Research in the Parkinson’s Progression Markers Initiative, a research program aiming to contribute to disease diagnosis and treatment. Launched in 2010 by the Michael J. Fox Foundation and a group of academic researchers…
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