Using a roundworm animal model, researchers identified a crucial mechanism for how signals from the environment can be combined with genetic susceptibility to influence the development of Parkinson’s disease. Mutations in the TNK2 gene, which have been reported in people with familial Parkinson’s, were found to lead to…
Insightec’s incision-free brain “surgery” technology — Exablate Neuro — leads to significant and sustained reductions in tremors, mobility problems, and other motor symptoms in advanced Parkinson’s disease patients with a fluctuating response to standard medications. That’s according to one-year data from a pivotal trial (NCT03319485) that tested the…
Havas Health Plus and the American Parkinson Disease Association (APDA) have launched a guide to intimacy meant to help Parkinson’s patients and their partners deepen their connections and improve their sexual life. Sexual dysfunction is common among people with Parkinson’s, and other symptoms such as rigidity,…
C4X Discovery (C4XD) has launched PatientSeek, a precision medicine platform that can help identify which people, including those with Parkinson’s disease, will likely benefit most from new therapies, based on their genetics. The launch follows a research collaboration with the Garvan Institute of Medical Research, Australia, which validated…
Women using a specific type of blood cholesterol-lowering medication, called lipophilic statins, for at least five years may have a lower risk of developing Parkinson’s disease, according to data from more than 70,000 women followed for 15 years in France. The results showed a dose-dependent effect, with lower Parkinson’s…
The Michael J. Fox Foundation for Parkinson’s Research (MJFF) has awarded a second $500,000 grant to NRG Therapeutics supporting more research into its potential disease-modifying therapy for Parkinson’s disease. The new funding comes after the successful completion of a previous MJFF-funded project that set out to investigate how NRG’s small…
Among several atypical antipsychotics, Nuplazid (pimavanserin) seems to be the most effective at easing Parkinson’s disease psychosis (PDP) while sparing motor function, according to a review study. Clozapine, used off-label in people with Parkinson’s, also helped, but its effect was not as large and patients were more…
Deep brain stimulation (DBS) is more effective at easing nonmotor symptoms and improving life quality for people with the postural instability and gait disturbance (PIGD) subtype of Parkinson’s disease than for those with the tremor-dominant (TD) subtype, a study showed. While previous studies have suggested different effects of…
LisCure Biosciences is teaming up with Celltrion to identify and develop oral therapies targeting the gut microbiome — the population of microorganisms living in the gastrointestinal tract —for people with Parkinson’s disease, the company announced. Under the collaboration, the South Korean companies aim to develop orally available live biotherapeutic…
Certain regulators of protein balance are suppressed in people with sporadic Parkinson’s disease and in those with familial disease linked to G2019S, the most common disease-causing LRRK2 gene variant, according to a study of patient-derived skin cells. These findings suggest shared underlying mechanisms between both types of Parkinson’s,…
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