News

Phase 3 trial of prasinezumab in early-stage Parkinson’s planned

Roche said it will launch a Phase 3 trial testing prasinezumab, an anti-alpha-synuclein antibody, as a potential treatment for early-stage Parkinson’s disease. The decision follows data from two Phase 2 trials showing prasinezumab had potential clinical efficacy at slowing motor symptom progression and reducing motor complications as an add-on…

Ambio ibogaine program treats Parkinson’s, other diseases

A new clinical program will use ibogaine, a naturally occurring psychedelic, to treat neurodegenerative conditions including Parkinson’s disease. Ambio Life Sciences, which hosts other ibogaine programming and participates in scientific research about the drug, soft-launched the program in February. It is the first of its kind in the…

Aged neurons don’t respond normally to stress: Study

Aging interferes with the way neurons, or nerve cells, respond to stress, making them more susceptible to damage and more likely to contribute to neurodegenerative diseases such as Parkinson’s, according to a study in cells and brain tissue. “It’s the neuronal equivalent of being so stressed that you catch…

Stress sensor GADD45G may be new therapeutic target

Researchers in Texas have discovered a promising therapeutic target for neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Using a mouse model of Alzheimer’s disease, they found that blocking the stress sensor GADD45G in astrocytes, which are star-shaped cells that support neurons, reduced the buildup of toxic proteins…

Casma to develop CSM-101 as treatment for Parkinson’s

Casma Therapeutics said it will develop CSM-101 as a potential disease-modifying oral treatment for people with Parkinson’s disease and Gaucher disease. CSM-101 is a first-in-class small molecule designed to activate the calcium channel TRPML1, a key regulator of lysosomal function and autophagy, a process in which cells deliver…

Rune Labs, Parkinson’s Foundation to study digital biomarkers

Rune Labs and the Parkinson’s Foundation are partnering on a clinical program to identify genetic and digital biomarkers showing how genetics and daily symptoms are connected in people with Parkinson’s disease, with the aim of speeding diagnosis, improving clinical trial design, and supporting the development of more targeted treatments. The…