Marisa Wexler, MS, senior science writer —

UB-312, an experimental vaccine targeting aggregated and toxic forms of alpha-synuclein to treat Parkinson’s disease, was generally well tolerated at multiple doses in a clinical trial in healthy adults. Study data also suggest that UB-312 prompted an immune response, as designed, against the alpha-synuclein protein. With two doses now selected…

Parkinson’s patients who have more severe motor symptoms are more likely to derive a benefit from high-cadence dynamic cycling, an analysis of two cycling studies indicates. Findings were in the study “Body Mass Index and Exercise Effort Influences Changes in Motor Symptoms After High-Cadence Dynamic Cycling in…

Electrical implants in the spine can clear up feelings of lightheadedness upon standing — the result of a condition called orthostatic hypotension — in people with neurological disorders like Parkinson’s disease, new research shows. Orthostatic hypotension refers to a sudden drop in blood pressure when a person moves from…

Treatment with GT-02287, an experimental oral therapy for Parkinson’s disease, corrected numerous damaging abnormalities associated with Parkinson’s in cell models, according to new data shared at a recent conference. “The data we presented at the Synuclein Meeting demonstrates further encouraging disease modifying potential for patients with Parkinson’s disease who currently…

A loss of social support due to the COVID-19 pandemic is tied to poorer mental health and more severe cognitive problems in people with Parkinson’s disease, a study based on a patient and caregiver survey reported. The study, “Impact of Isolation During the COVID-19 Pandemic on…

Markers of age in the retina — the layer of tissue at the back of the eyeball chiefly responsible for sensing light — can be used to predict the risk of future Parkinson’s disease, a new study indicates. The study, “Retinal age gap as a predictive…

ND0612, an investigational formulation of carbidopa/levodopa delivered continuously via a subcutaneous pump, was generally well-tolerated for more than four years of treatment in a Phase 2 clinical trial of Parkinson’s patients, new data show. Findings reveal that the vast majority of adverse events (side effects) reported in…

Over-expressing a fly gene called clueless (clu) can lessen mitochondrial defects in fruit fly models of Parkinson’s disease, a new study reveals. The results also showed that CLUH, the human equivalent of the fly clueless gene, has a similar function, which may pave the way toward new treatment approaches for…

Treatment with oral IPX-203, Amneal Pharmaceuticals’ investigational extended-release carbidopa-levodopa (CD/LD) formulation, reduced “off” time by about 1.5 hours a dose, on average, compared to immediate-release tablets of the medication, according to data from a Phase 3 RISE-PD clinical trial. Top-line results from RISE-PD were announced last year. Detailed…

A surgery-like brain procedure called gamma knife thalamotomy may help to ease tremor in people with Parkinson’s disease, a new study highlights. The study, “Gamma Knife stereotactic radiosurgery as a treatment for essential and parkinsonian tremor: long-term experience,” was published in Neurología. Tremor is one of…