Lindsey Shapiro, PhD, science writer —

Lindsey earned her PhD in neuroscience from Emory University in Atlanta, where she studied novel therapeutic strategies for treatment-resistant forms of epilepsy. She was awarded a fellowship from the American Epilepsy Society in 2019 for this research. Lindsey also previously worked as a postdoctoral researcher, studying the role of inflammation in epilepsy and Alzheimer’s disease.

Articles by Lindsey Shapiro

P2B001 effective in key patient subgroups: Phase 3 trial data

P2B001, an investigational combination therapy (pramipexole/rasagiline) from Pharma Two B, controlled Parkinson’s disease symptoms better than either of its individual components regardless of patients’ age or disease severity, according to subgroup analyses from a Phase 3 trial. As with previous analyses involving all participants, P2B001 was as effective…

Dopamine neurons may be more diverse than thought

A specific subset of dopamine-producing nerve cells in the brain appear to respond to movement acceleration and correspond with the region where cell death is particularly pronounced in Parkinson’s disease, according to a recent study. These neurons were responsive only to movement, and not to rewarding stimuli, which long…

Bladder problems in patients linked to distinct brain networks on MRI

Parkinson’s disease patients with urinary incontinence (UI) exhibit distinct brain activity networks compared with patients without the bladder symptom, according to a recent study. Urinary incontinence was linked to stronger functional interactions between brain regions implicated in Parkinson’s disease and others linked to brain-bladder control. Findings overall “will provide…

LRRK2 mutations may curb certain immune cells’ ability to clear waste

Mutations in the LRRK2 gene might contribute to Parkinson’s disease by suppressing the activity of lysosomes, the cell compartments responsible for clearing misfolded proteins and other cellular waste, according to a recent study. In cell culture experiments, Parkinson’s-associated LRRK2 mutations were linked to reduced lysosome activity in microglia and macrophages,…