Lindsey Shapiro, PhD, science writer —

Lindsey earned her PhD in neuroscience from Emory University in Atlanta, where she studied novel therapeutic strategies for treatment-resistant forms of epilepsy. She was awarded a fellowship from the American Epilepsy Society in 2019 for this research. Lindsey also previously worked as a postdoctoral researcher, studying the role of inflammation in epilepsy and Alzheimer’s disease.

Articles by Lindsey Shapiro

Changes in Brain Architecture Tied To Poor Bimanual Coordination

Small-scale, or microstructural, brain alterations observed on the MRIs of people with Parkinson’s disease were associated with worse bimanual coordination, a type of complex movement, a study found. “[D]istinct changes in microstructure cause an impediment of structures involved in attention, working memory, executive function, motor planning, motor control, and…

New Role for Alpha-synuclein Uncovered by Researchers

The buildup of alpha-synuclein in cells and brain tissue in Parkinson’s disease patients is linked to the disruption of processes involved in degrading RNA, the template used for protein production, a study has found. The findings uncover a new biological role for the alpha-synuclein protein, its researchers said. “Our…

Trial to Test Wearable ‘Exoskeleton’ as Training Aid for Gait Problems

A clinical trial will evaluate how well a wearable “exoskeleton” device aids rehabilitation training to improve walking mechanics and neuromuscular function in people with Parkinson’s disease. “Findings linked with the proposed study will likely give substantial solutions to the management of gait and postural disorders (posture, balance, and gait) in [Parkinson’s]…

Blockade of PAAN Enzyme Improves Motor Function in Mice

Inhibition of a DNA-destroying enzyme called PAAN protected against nerve cell death and lessened motor symptoms in mouse models of Parkinson’s disease, a study found. The findings overall demonstrate an important role for PAAN in Parkinson’s disease mechanisms and highlight the therapeutic potential of targeting this enzyme as a…

Nanoparticles Restore Mitochondrial Function in Mouse Study

A team of researchers has designed nanoparticles able to restore the function of mitochondria — cells’ energy production centers — and improve motor behavior in a mouse model of Parkinson’s disease. Experiments in cell cultures revealed that the nanoparticles could restore function of reversibly damaged mitochondria and promote the…

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