Changes in Protein Structure May Act as Parkinson’s Biomarkers

Changes in the structure of 76 proteins in the cerebrospinal fluid (CSF) of people with Parkinson’s disease were seen when compared with those of healthy individuals, a study reported. Its researchers believe their work is the first to look at protein structure — rather than abundance — to identify potential…

Structure of Toxic Protein Aggregates Opens Door to Novel Parkinson’s Disease Treatments

In a recent study led by researchers from the UCLA-DOE Institute entitled “Structure of the toxic core of α-synuclein from invisible crystals” published in Nature, an ultra-high-resolution structure of crystals from the core of alpha-synuclein fibrils, toxic assemblies formed in…

New Technique Based on Nanopores for the Study of Protein Structure

Researchers at the University of Pennsylvania recently reported a new technique based on nanopores for the study of protein structure. The technique can potentially be applied in the study of protein aggregation that occurs in neurodegenerative disorders like Parkinson’s disease. The study was published in the journal…