Proteostasis regulators are potential Parkinson’s targets, biomarkers

Certain regulators of protein balance are suppressed in people with sporadic Parkinson’s disease and in those with familial disease linked to G2019S, the most common disease-causing LRRK2 gene variant, according to a study of patient-derived skin cells. These findings suggest shared underlying mechanisms between both types of Parkinson’s,…

GPNMB Protein May Be Parkinson’s Biomarker, Treatment Target: Study

Levels of a protein called glycoprotein nonmetastatic melanoma protein B (GPNMB) are elevated in the blood of people with Parkinson’s disease, indicating the protein may be a biomarker for the neurological disorder, according to a new study. GPNMB also helps to promote the toxic aggregation of alpha-synuclein protein in…

New Parkinson’s Treatment Target – Drp1 Protein Linked to Sense of Smell – Found in Rat Model, Study Reports

A new potential target for treating Parkinson’s, a protein named Drp1, has been identified using a rat model of the disease, a study reported. The target was found to play a central role in the underlying cause of the degeneration and inflammation of nerve cells…