Two imaging markers can help pinpoint sites of brain inflammation in people with Parkinson’s disease, according to a study. The findings shed light on the role of brain inflammation in disease progression and can help pave the way for more precise diagnostics and targeted therapies. “We are excited about…
Scientists have proposed a new way to classify Parkinson’s disease based on biological changes associated with the disorder. “Without looking at the biology, you can’t get answers. And without answers, we won’t have much-needed breakthroughs in Parkinson’s,” Anthony Lang, MD, a researcher at the Krembil Brain Institute in Canada,…
Small vesicles that contain the protein alpha-synuclein may help distinguish Parkinson’s disease patients from healthy people, according to a meta-analysis. When isolated from easily accessible samples, like the blood, these vesicles may “reflect changes in the brain,” researchers wrote in “Extracellular Vesicles for the Diagnosis of Parkinson’s…
Aerobic exercise stabilizes progression of motor symptoms and improves cognitive function in people with Parkinson’s disease, according to additional data from the Park-in-Shape clinical trial. Notably, these benefits were found to be associated with increased neuronal connectivity in brain areas controlling such functions and with reduced brain atrophy (shrinkage). These…
Visual dysfunction and its underlying brain changes can identify Parkinson’s disease patients at higher risk of cognitive decline, who might benefit most from future clinical trials, according to two new studies. The studies, “Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson’s disease”…
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