Vitamin B12 can prevent the formation of and destroy alpha-synuclein aggregates in the brain, lowering their toxicity and potentially helping to alleviate Parkinson’s disease, according to a study. The study, “Vitamin B12 inhibits α-synuclein fibrillogenesis and protects against amyloid-induced cytotoxicity,” was published in the journal…

Measuring the amount of alpha-synuclein in tiny vesicles collected from blood serum may help diagnose early Parkinson’s and identify patients with different types of this disease. The study with that finding, “Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson’s Disease,” was published…

Alpha-synuclein levels in the gut are linked to Parkinson’s disease, indicating that gut alpha-synuclein may be used in combination with other disease biomarkers to facilitate patients’ diagnosis, a review study found. The study, “Diagnostic utility of gut α-synuclein in Parkinson’s disease: A systematic review and…

People who have appendectomies have more than three times the risk of developing Parkinson’s disease, according to the findings of a U.S. large-scale study. The study, “Parkinson’s Disease Is More Prevalent In Patients With Appendectomies: A National Population-Based Study,” will be presented during Digestive Disease Week (DDW) 2019,…

A new test can analyze cerebrospinal fluid samples and help measure how many toxic aggregates of alpha-synuclein can be found in the brains of patients with Parkinson’s disease. The new assessment strategy was developed by Japanese researchers and was reported in a study, “Ultrasonication-based rapid amplification of…

Lack of tissue oxygenation associated with episodes of upper airway obstruction in patients with obstructive sleep apnea syndrome (OSAS) may increase the levels of alpha-synuclein in the blood and may contribute to the development of Parkinson’s disease, a study says. The study, “Plasma α‐synuclein levels are increased…

A modified form of the alpha-synuclein protein can be found in the salivary gland tissue of Parkinson’s patients even in the early stages of the disease, suggesting the protein could be a potential biomarker for this neurodegenerative disorder, a study reports. The study, “Nitrated alpha-synuclein in minor salivary gland biopsies…

Tracer compounds with high affinity and selectivity to alpha-synuclein deposits have been identified that could be used to detect and track Parkinson’s disease progression, AC Immune announced. Findings were recently presented in the study, “Identification and Characterization of Selective and High Affinity Small Molecules for Positron Emission…