People with Parkinson’s disease who have mild cognitive changes before deep brain stimulation (DBS) are not more likely to develop dementia later in life than those whose cognitive function was normal before the surgery, a Danish study has found. Instead, the researchers observed that dementia was more likely…
Rune Labs and the Parkinson’s Foundation are partnering on a clinical program to identify genetic and digital biomarkers showing how genetics and daily symptoms are connected in people with Parkinson’s disease, with the aim of speeding diagnosis, improving clinical trial design, and supporting the development of more targeted treatments. The…
Cure Parkinson’s is funding SLEIPNIR, a multiarm clinical trial platform that will simultaneously test up to three disease-modifying treatments for Parkinson’s disease — assessing whether any of them can engage with their intended targets in the brain. The results are expected to help decide if these treatments should…
Many years ago, my dad began to lose his sense of smell. A doctor told him that it was likely because of his nasal polyps — small, noncancerous growths that can be caused by long-term inflammation. These polyps are relatively common, affecting up to 40% of the…
Living with Parkinson’s disease means constantly negotiating the unpredictable: tremors that come and go without warning, stiffness that turns a short walk into a major expedition, fatigue that hits like a wave. It’s easy, almost automatic, to want to handle it all quietly. I don’t want to be a…
The first patient has been dosed in a pivotal Phase 2/3 clinical trial testing BHV-8000, a brain-penetrant oral small molecule that Biohaven Therapeutics is developing as a disease-modifying therapy for neuroinflammatory conditions, including Parkinson’s disease. The clinical trial (NCT06976268) is evaluating the effectiveness and safety of BHV-8000…
Last month, in honor of Mother’s Day, I shared some lessons I learned from my mom that have helped me through my journey with Parkinson’s disease. This month, I wanted to share a bit about my dad and the journey we both went through when I was diagnosed.
Microglia-driven inflammation plays an early, key role in the development of neurodegenerative diseases, including Parkinson’s disease, by contributing to the spread of abnormal protein clumps in the brain. That’s according to study results published by a team of South Korean researchers and highlighted by Zyversa Therapeutics, which recently…
Multiple doses of apathy treatment IRL757 for Parkinson’s disease and other neurological disorders were well tolerated and presented a favorable pharmacological profile in the second part of a Phase 1 trial. This part of the Phase 1 clinical trial (NCT06493045) tested the safety and tolerability of multiple ascending…
“Squash the bug, Barry!” my friend Dave yelled across the boxing gym. Our other friend Barry had been on his way to get a drink of water and had frozen. When Dave shouted, Barry lifted one leg and stomped it down (picture somebody squishing a bug), and that got him…
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