News

UK platform trial to test repurposed therapies for Parkinson’s

A new trial platform that will test multiple disease-modifying treatments for Parkinson’s disease is now recruiting participants in the U.K., Cure Parkinson’s has announced. The program, called EJS ACT-PD, will initially test two therapies, telmisartan and terazosin, against a shared placebo. A third treatment, ursodeoxycholic acid, is expected…

Mission raises $13.3M for Parkinson’s treatment Phase 1b trial

Mission Therapeutics has raised $13.3 million to advance MTX325, its treatment candidate for Parkinson’s disease, into a Phase 1b clinical trial in Parkinson’s patients. The funding comes after the company successfully completed a Phase 1a study demonstrating the treatment can enter functional brain tissue in healthy volunteers.

Wearable device aims to help researchers track Parkinson’s

Clario and the University of Oxford are testing a wearable device to see how effective it is at tracking subtle changes in Parkinson’s disease, with the aim of improving clinical research. Clario’s Opal wearable sensor device has demonstrated the ability to detect motor changes faster than traditional clinical…

Parkinson’s gene therapy reduced alpha-synuclein in animal models

Shape Therapeutics’ SHP-201, an experimental gene therapy for Parkinson’s disease, significantly reduced the levels of alpha-synuclein — a protein that plays a key role in the development of the neurodegenerative condition — in the brain of mouse and nonhuman primate models, according to new preclinical data released by…

Parkinson’s therapy is tolerated well, clearing path for Phase 2 trial

An experimental therapy being developed by Herantis Pharma for Parkinson’s disease was well tolerated and able to penetrate the blood-brain barrier (BBB), a semipermeable membrane that prevents certain substances, including medications, from entering the brain. That’s according to top-line data from a Phase 1b trial (NCT06659562), which…