Pretreatment with curcumin, a compound found in the spice turmeric, helped protect motor function in a mouse model of Parkinson’s disease, a new study found. Findings suggest that curcumin helped protect dopamine-producing nerve cells by activating autophagy, a process cells use to recycle unneeded material. This cellular recycling process,…
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New funding from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) will support lab studies of a one-time gene therapy candidate for Parkinson’s disease. Shape Therapeutics, a U.S. company that investigates RNA-based therapies, will use the newly awarded research grant to conduct preclinical studies of its…
The U.S. Food and Drug Administration (FDA) has granted regenerative medicine advanced therapy (RMAT) designation to sasineprocel (ANPD001), an experimental cell therapy to treat Parkinson’s disease. The designation, given to promising regenerative therapies (treatments that aim to replace or restore disease-damaged tissue) that could substantially improve care for serious diseases, …
Low dopamine levels disrupt nerve circuits in the brain in Parkinson’s disease — but a new study indicates that different brain circuits show different, even opposite, types of changes. The study’s findings shed new light on how brain circuits are affected by Parkinson’s. The researchers said their data also suggest…
Higher blood levels of a specific ratio between two fats, called ceramides, may help identify people with Parkinson’s disease who are more likely to develop thinking and memory problems, according to a new study. A higher Cer 24:1/Cer 24:0 ratio was closely associated with worsening cognitive impairment and remained…
Alzheimer’s-related brain changes may not be a major contributor to earlier cognitive problems in people with Parkinson’s disease who have not developed dementia, a new study suggests. Researchers found that blood levels of phosphorylated tau-217 (p-tau217), a blood marker of early Alzheimer’s disease, were not clearly associated with…
Patients participating in a three-week digital intervention program designed to complement levodopa, the standard treatment for Parkinson’s disease, showed measurable structural and functional changes in brain networks involved in movement, accompanied by meaningful easing of motor symptoms. The pilot study evaluated Remepy‘s investigational hybrid therapy, Hybridopa, in…
Language-based analyses of how people with Parkinson’s disease tell stories may provide a more nuanced look at how the disease affects memory and cognition, according to a study. In fact, the data suggest that a language-based approach can distinguish between people with or without Parkinson’s more accurately…
Taking part in a structured table tennis program may help improve movement, balance, and walking endurance in people with Parkinson’s disease, according to a small pilot study that found participants were able to walk about 20 feet farther after completing the program. Participants also self-reported fewer depressive symptoms by…
A tablet-based set of video games called SmartMe&You reflected cognitive status in people with Parkinson’s-related mild cognitive impairment or mild-to-moderate dementia, a new study found. “These video games have the potential to serve as a reliable, unsupervised digital home telemonitoring cognitive battery for periodic assessment of cognitive status in…
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