Heavy coffee consumption results in lower dopamine activity in the striatum, a brain region affected in Parkinson’s disease, and does not ease motor symptoms in early diagnosed patients who have not yet been treated for the neurological disease, a study has found. However, coffee consumption before brain imaging was…
People who carry the G2019S mutation in the LRRK2 gene, the most common one associated with Parkinson’s disease, have a 10 times higher risk of developing the disease, but the risk increases to 27 times if mutations in other genes are also present. G2019S carriers developed the disease earlier, but, despite…
Recognizing cognitive decline and low sex drive in people with Parkinson’s disease and depression could aid the early diagnosis and better management of the disease, according to researchers in Iran. While it’s not known if treating depression may ease other nonmotor symptoms, “these findings could be beneficial for…
Scientists have harnessed the power of a protein-screening technology to identify a novel inhibitor of AAK1, an enzyme linked with Parkinson’s disease, a development that could speed the discovery of new therapies. Developing inhibitors for these specific enzymes, called kinases, has proven a difficult task due to the similar…
Lucy Therapeutics‘ (LucyTx) overall funding haul has grown to $36 million with the addition of $12.5 million more to support the company’s mitochondrial platform to develop new therapies for Parkinson’s disease. The total funding will also buttress the development of Lucy’s therapeutic pipeline for Alzheimer’s disease and…
The U.S. Food and Drug Administration (FDA) has granted regenerative medicine advanced therapy (RMAT) designation to bemdaneprocel, a cell therapy BlueRock Therapeutics, a subsidiary of Bayer, is developing to treat Parkinson’s disease. RMAT designation is granted to therapies that have shown potential to treat serious or life-threatening…
A first-of-its kind study has identified key genes in the brain that explain why Black Americans have a lower incidence of Parkinson’s disease, but are at heightened risks for other brain disorders, including stroke and Alzheimer’s. “This landmark work enriches our understanding of the role of genetic ancestry in…
Aside from easing motor symptoms of Parkinson’s disease, deep brain stimulation (DBS) may also slow disease progression by keeping misfolded forms of alpha-synuclein from building up in the brain and harming nerve cells, a preclinical study involving rat brain cells suggests. If the findings hold true in humans, they…
Researchers at the Icahn School of Medicine at Mount Sinai have identified LRRK2 gene mutations as a common element in both inflammatory bowel disease (IBD), an umbrella name for disorders marked by prolonged inflammation of the digestive tract, and Parkinson’s disease. The study also identified genes involved in inflammation…
Low to moderate doses of CAP-003, a gene therapy in the pipeline from Capsida Biotherapeutics, increased levels of glucocerebrosidase (GCase), an enzyme that’s missing or faulty in some people with Parkinson’s disease, in the brain of nonhuman primates. Given as a one-time infusion into the vein, or intravenously,…
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