Scientists have developed a nanoparticle drug delivery system designed to enhance brain delivery of levodopa, the mainstay treatment for Parkinson’s disease, while also lowering a type of cellular damage called oxidative stress that’s implicated in the neurodegenerative condition. The system was able to improve motor function in a…
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The use of deep brain stimulation — in which an electrode is surgically implanted in the brain — may hold promise to reverse inflammation, a key driver of Parkinson’s disease progression, according to a new study led by researchers in Germany. “Deep brain stimulation halts inflammatory changes in Parkinson’s…
Data from a brief gait and posture assessment using wearable sensors — taking just a few minutes in the clinic — could help to accurately predict the risk of falls in the near future with Parkinson’s disease, a recent clinical study reported. Scientists at the University of Oxford in…
Taking steps to increase patient education about osteoporosis — a bone-weakening condition that’s common in people with Parkinson’s disease — could potentially lower the risk of falls and encourage higher calcium intake for stronger bones among those with both conditions, a new study suggests. The researchers recommended distributing an…
Treatment with investigational antibody therapy prasinezumab tended to slow the progression of motor symptoms in people with early-stage Parkinson’s disease in a Phase 2b trial, with particularly pronounced benefits among those also receiving levodopa. However, the difference between prasinezumab and a placebo in the overall study population…
Tracking how the brain responds to different emotions may be an effective way to detect Parkinson’s disease, a new study posits. The study, “Exploring Electroencephalography-Based Affective Analysis and Detection of Parkinson’s Disease,” was published in Intelligent Computing. Along with its characteristic motor symptoms, Parkinson’s can…
Adaptive deep brain stimulation (aDBS) resulted in long-lasting relief from bradykinesia and walking difficulties in a 61-year-old Parkinson’s disease patient, whose quality of life also improved, researchers wrote in a case report about the man. Unlike conventional DBS (cDBS), where electric brain stimulation is constant or adjusted manually…
In people with Parkinson’s disease, shrinkage in tremor-related brain areas is associated with the progression of motor symptoms, according to a study. In the brain’s gray matter, which contains cell bodies of neurons, this shrinkage, or atrophy, of tremor-related regions and the whole brain over two years was associated…
A diet rich in antioxidants — such as vitamins A, C, E, and selenium and zinc — may help most older adults counter becoming frail, but its benefits are less certain for people with Parkinson’s disease, a study drawing on U.S. data suggests. Findings indicate that the disease’s complex…
A 45-year-old man initially deemed to have depression was later diagnosed with parkinsonian syndrome following a skin biopsy that detected alpha-synuclein, a protein that forms toxic clumps in the brains of people with Parkinson’s disease, according to a case study from researchers in Miami. After receiving a combination of carbidopa…
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