NeuroDerm received a green light from the European Medicines Agency (EMA) for the main design elements of the amended iNDiGO trial evaluating ND0612 as a treatment for Parkinson’s disease in patients on levodopa with motor fluctuations. The letter NeuroDerm…
Forty-two percent of Parkinson’s patients who took ND0612H were able to eliminate periods during the day when their symptoms recurred because their therapy had worn off, according to a Phase 2 clinical trial. The 006 trial (NCT02577523) of NeuroDerm’s IV-delivered therapy dealt with what is known as Parkinson’s off time. The time…
CVT-301 significantly improves movement in Parkinson’s disease patients at times of the day when the impact of other therapies diminishes, according to a Phase 3 clinical trial. The impact of a Parkinson’s treatment varies during the day. It is often most effective right after a patient takes it, and least…
Australia’s GKC (Global Kinetics Corp.) has enrolled the first of more than 400 Parkinson’s patients in its APPRISE clinical trial — a multicenter, randomized study that will determine whether the Personal KinetiGraph (PKG) system is appropriate for identifying which patients need to change the clinical management of their disease. The trial,…
A strain of influenza commonly known as swine flu could trigger the development of Parkinson’s disease, according to a study in mice. Mice infected with the H1N1 strain lost a lot of their brain neurons, even long after the virus struck. Neuron loss is a hallmark of Parkinson’s. Importantly, vaccination against the…
Merz Neurosciences says two doses of its therapy Xeomin (incobotulinumtoxin A) effectively treat chronic drooling among patients with Parkinson’s disease and other illnesses. The company, a unit of Germany’s Merz Pharma, will present results from the SIAXI Phase 3 clinical trial (NCT02091739) June 7 at the 21st International Congress of Parkinson’s Disease…
Researchers found that clumps of faulty protein involved in Alzheimer’s, Parkinson’s, and Huntington’s disease cause brain damage by invading and rupturing small vesicles in neurons. The study, “Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins,” published in the journal Acta Neuropathologica, bring…
Researchers have found new biomarkers that may improve the ability of clinicians to predict which patients in the early stages of Parkinson’s disease will suffer cognitive impairment within the first three years of their diagnosis, a new study says. These biomarkers include deficits in dopaminergic circuits (neurons that produce dopamine, which…
The antipsychotics Clozaril (clozapine, or CLZ) and Nuplazid (pimavanserin, or PIM) are potential treatments for Parkinson’s disease psychosis (PDP) in patients with idiopathic Parkinson’s disease (iPD), whose cause is unknown. However, their use is currently limited and further research is necessary, according to…
Researchers at the Karolinska Institute in Sweden have identified the underlying neural mechanisms responsible for the reduced sense of touch and smell which Parkinson’s patients experience in early stages of the disease. A better understanding of these processes can help in the development of new early diagnostic methods. Their findings resulted…
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