A planned Phase 2 clinical trial evaluating ANVS401, Annovis Bio‘s lead investigational therapy for people in the early stages of Alzheimer’s and Parkinson’s disease, has received approval from a central institutional review board (IRB). An IRB is an administrative body responsible for protecting the rights and welfare of human research…
Preliminary results from the PD GENEration study demonstrate that comprehensive genetic testing and counseling, and the identification of rare genetic mutations linked to Parkinson’s disease, is feasible for the Parkinson’s community at large. Launched in 2019 through the Parkinson’s Foundation and supported partly by Biogen, the study…
Many Parkinson’s disease patients in the U.K. feel challenged by the COVID-19 pandemic and the restrictions it has placed on social interaction, reporting problems ranging from canceled appointments and limited exercise to worsening symptoms, according to a survey conducted by Parkinson’s UK and Lancaster University. “Unfortunately this report shows…
When given to people at earlier stages of Parkinson’s disease, deep brain stimulation (DBS) reduces the complexity of their treatment, while safely providing long-term motor benefits and possibly slowing disease progression, data from a five-year pilot trial suggests. A planned Phase 3 study has already received the…
Ongentys (opicapone) has been approved in Japan as an oral, add-on daily treatment for Parkinson’s disease patients experiencing off periods while on a levodopa/carbidopa regimen. This decision adds Japan to the list of countries where Ongentys is available as an add-on treatment for Parkinson’s motor symptoms, including the U.S. and…
The University at Buffalo has received a $2.2 million grant from the National Institute of Neurological Disorders and Stroke to develop a new method for diagnosing Parkinson’s disease before the onset of clinical symptoms, according to a university press release. Called “Molecular Segregation of Parkinson’s Disease…
The four winners of the Michael J. Fox Foundation (MJFF) and Sage Bionetworks Parkinson’s disease (PD) challenge to create new ways of using everyday technology to benchmark and predict disease progression remotely — including at home — have been announced. Called the Biomarker and Endpoint Assessment…
The U.S. Food and Drug Administration (FDA) has approved the Percept PC Neurostimulator by Medtronic, designed to allow for a more individualized use of deep brain stimulation therapy in people with Parkinson’s disease and related disorders. While this device is the fourth deep brain stimulation (DBS) system to…
Alterations in the levels of melatonin — the hormone that controls sleep-wake cycles — circulating in the blood are associated with certain non-motor symptoms of Parkinson’s disease, namely sleep disturbances, gastrointestinal issues, and heart problems. The study with that finding, “Elevated Plasma Melatonin Levels…
Lower than usual activity in a complex that recycles proteins in cells — called the proteosome — leads to an age-related buildup of protein aggregates in the brains of fish, similar to that seen in neurodegenerative diseases such as Parkinson’s, a study reported. Low proteasome activity…
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