News

Stalevo (levodopa, carbidopa, and entacapone combination therapy) may be more effective but seems to be associated with more side effects than other medications to treat early Parkinson’s disease, researchers report. The study, “Levodopa/carbidopa/entacapone for the treatment of early Parkinson’s disease: a meta-analysis,” was…

A Phase 2/3 trial (Study 301) testing Addex Therapeutic’s candidate dipraglurant for people with levodopa-induced dyskinesia associated with Parkinson’s disease (PD-LID) has been postponed — until further notice — due to the continued spread of COVID-19 in Europe and the U.S., where the trial was set to…

An investigational gene therapy, called VY‐AADC01, boosts motor responses to levodopa that is given intravenously —particularly at a low dose — in people with Parkinson’s disease, a sub-study within a Phase 1b trial shows. These findings, along with positive data from the main PD-1101 study (NCT01973543), support the potential…

Biomarkers of brain inflammation could provide a useful means for classifying Parkinson’s and Alzheimer’s patients and defining the mechanisms underpinning each person’s disease. Testing for these biomarkers could support clinicians in providing precision medicine, by helping people with the progressive neurodegenerative disorders to choose treatments with a greater…

An important signaling pathway that helps protect brain cells from neurodegenerative diseases such as Parkinson’s disease is also required for sleep in fruit flies and zebrafish, according to a study. The findings support a link between sleep loss and neurodegenerative diseases.

With a focus on the unpredictable path often facing caregivers, the Parkinson’s Foundation is again hosting a free-of-charge, English-Spanish bilingual summit for those helping Parkinson’s patients with their daily needs. But the Care Partner Summit (Cumbre Para Cuidadores) on Saturday, May 16, will be exclusively online — due the coronavirus, COVID-19,…

Scientists discovered a potential link between Parkinson’s disease and a gene that is affected by a neurotoxin made by blue-green algae. The discovery adds to a growing body of evidence that Parkinson’s can be influenced by environmental factors. The study, “Analysis of DNA methylation…

Using an engineered sound-sensitive protein, researchers have developed neurons that can be activated by ultrasound. This could be useful in studying, and even developing therapies for, neurological diseases, including Parkinson’s. The study, “Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein,” was published in Nano Letters.

Fatigue may compromise and predict Parkinson’s patients’ mobility and their ability to walk over long distances, according to a recent study. The results of the study, “Can fatigue predict walking capacity of patients with Parkinson’s disease?” were published in Arquivos de Neuro-Psiquiatria. Lack of energy, or…

Immune cells known as “natural killer” (NK) cells appear to fight the cellular changes that lead to conditions such as Parkinson’s disease. Understanding how they do this may lead to new therapies for the neurodegenerative disorder, according to a study from the University of Georgia.