Scientists have designed a so-called “organ-on-a-chip” device that can grow dopaminergic neurons — the brain cells most affected in people with Parkinson’s disease — in a 3D environment where they are more like real neurons in the brain, a study shows.
Scientists at the University of Copenhagen (UCPH) in Denmark have developed an artificial intelligence (AI) tool to monitor and track the dynamics of protein movement and function, which can advance the understanding behind neurodegenerative disorders such as…
Constipation and sleep behavior disorder are strongly associated with future decline in some cognitive measures in people — especially men — newly diagnosed with Parkinson’s disease, a study suggested. Its researchers recommend early assessment of sleep disorders and constipation to help predict cognitive changes in later disease stages. …
Stem cells transplanted into the facial tissue of two people with Parkinson’s disease led to sustained reductions in motor and non-motor symptoms, lower medication doses, and a better quality of life, a case study reported. Its authors recommended further investigation into…
People with early-onset Parkinson’s disease caused by mutations in the PRKN or PINK1 genes have high levels of the pro-inflammatory immune signaling protein interleukin-6 and mitochondrial DNA in the blood, which may…
Lower-than-usual levels of the protein SIRT1 are evident in the blood of people with Parkinson’s disease, and correlate with greater disease severity and cognitive impairment, a study reported. A blood test of SIRT1 levels, for this reason, may serve as a biomarker…
Mutations in the PARK7 gene, known to cause early onset Parkinson’s disease, result in low levels of a protein called DJ-1 that is essential for nerve cell health, a study revealed. In fixing a protein processing malfunction in cells derived from members of…
Neupro patches placed on the shin caused significantly less skin irritation and itching in people with Parkinson’s’ disease who previously had site reactions when these transdermal patches were applied elsewhere, a new study has found. The patch’s effectiveness as a…
In a real-world clinical setting, Neupro Patches (rotigotine) eased the clinical signs and symptoms of Parkinson’s disease, with more than 70% of patients reporting mild improvement or better, including those 80 years and older, a real-world study shows. …
The number of people with early-stage Parkinson’s disease who reported sleep disturbances increased over the course of a five-year longitudinal study, with insomnia being the most common sleep problem among this patient population. The frequency of other sleep problems such as…
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