The impact of deep brain stimulation (DBS) in improving motor function in people with Parkinson’s disease may be related to a patient’s response to levodopa therapy, and to the type of DBS administered, according to a small study. Patients who responded to levodopa demonstrated better…
People with Parkinson’s disease who failed to take their medication as prescribed — meaning, were nonadherent — showed no difference in measures of health-related quality of life (HRQoL) than those who were fully adherent, a questionnaire study of a patient group found. This finding…
Machine-learning analysis of video recordings of people thought to have Parkinson’s disease as they performed specific motor tasks was able to distinguish these suspected cases from healthy people, as well as Parkinson’s patients from those with essential tremor, a pilot study confirmed. This non-invasive,…
A re-examination of blood samples from people with early Parkinson’s disease in a Phase 3 trial — in which Dynacirc, a blood pressure medication, failed to slow disease progression — found that those with higher blood levels of Dynacirc were slower to start an antiparkinson therapy and needed lower doses once…
Alterations in gut microorganisms found in the appendix of people with Parkinson’s disease were associated with elevated digestive bile acids that may play a role in disease development, a study has revealed. The discovery suggests targeting microbial-derived bile acids as a…
An extract from three plant species reduced signs of motor disturbances in rodent models of Parkinson’s disease and lessened the associated molecular defects of the cellular recycling process known as autophagy, a study showed. Further research is needed to confirm that…
People with Parkinson’s disease with symptoms affecting one side of the body, who were treated with focused ultrasound targeting the affected brain region, showed an improvement in motor features after four months, a small study reported. Side effects included involuntary movements, muscle weakness, speech problems,…
Later age at Parkinson’s disease onset is associated with high adherence to the MIND diet and benefits women more than three times as much as it does men, a study has shown. In contrast, adherence to the Greek Mediterranean diet significantly correlates…
A smartphone application designed to measure and monitor the walking mobility of people with Parkinson’s disease captured a 44% decrease in daily activities during the COVID-19 pandemic lockdowns, a study assessing the app reported. The lack of movement was due to confinement, not worsening disability, the…
Treatment with the antioxidant metal-alloy nanozyme reduced the build-up (aggregation) and transmission of disease-causing alpha-synuclein protein in the nerve cells and brains of a Parkinson’s disease mouse model, a study reported. Investigators believe these findings support further research to evaluate nanozymes as a Parkinson’s treatment.
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