Dose-dependent decreases in targeted fatty acids were seen with YTX-7739, an investigational therapy for Parkinson’s disease, suggesting the medicine engages its therapeutic target, according to the results of a Phase 1a multiple-ascending dose study in healthy volunteers.
Microbleeds found in the brains of people with Parkinson’s disease by magnetic resonance imaging (MRI) scans were associated with cognitive decline, a study demonstrated. Higher levels of a microbleed-associated biomarker also were found in patients with dementia. Moreover, a statistical analysis found the…
Gocovri (amantadine) more than doubled the daily time on levodopa-based therapies without any dyskinesia — involuntary, uncontrolled movements — in people with Parkinson’s disease compared to those given a placebo, an analysis of data from two Phase…
In light of Parkinson’s Awareness Month — starting April 1st — Parkinson Canada is calling for better awareness of the neurodegenerative disorder, while supporting organizations dedicated to helping those impacted by it. This message is made more urgent by COVID-19, according to…
Several microRNAs in the blood of people with Parkinson’s disease differ from healthy controls, correlate with disease progression, and are associated with hallmarks of the disorder, a large-scale study reported. These findings support the possible use of microRNAs as biomarkers in…
Transplanting dopamine-producing nerve cells grown from monkeys’ own cells back into their brains relieved motor and depression symptoms associated with Parkinson’s disease, a study demonstrated. This approach avoided transplant-associated tissue rejection and supports further research as a treatment option for people…
The impact of deep brain stimulation (DBS) in improving motor function in people with Parkinson’s disease may be related to a patient’s response to levodopa therapy, and to the type of DBS administered, according to a small study. Patients who responded to levodopa demonstrated better…
People with Parkinson’s disease who failed to take their medication as prescribed — meaning, were nonadherent — showed no difference in measures of health-related quality of life (HRQoL) than those who were fully adherent, a questionnaire study of a patient group found. This finding…
Machine-learning analysis of video recordings of people thought to have Parkinson’s disease as they performed specific motor tasks was able to distinguish these suspected cases from healthy people, as well as Parkinson’s patients from those with essential tremor, a pilot study confirmed. This non-invasive,…
A re-examination of blood samples from people with early Parkinson’s disease in a Phase 3 trial — in which Dynacirc, a blood pressure medication, failed to slow disease progression — found that those with higher blood levels of Dynacirc were slower to start an antiparkinson therapy and needed lower doses once…
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