Markers of age in the retina — the layer of tissue at the back of the eyeball chiefly responsible for sensing light — can be used to predict the risk of future Parkinson’s disease, a new study indicates. The study, “Retinal age gap as a predictive…
ND0612, an investigational formulation of carbidopa/levodopa delivered continuously via a subcutaneous pump, was generally well-tolerated for more than four years of treatment in a Phase 2 clinical trial of Parkinson’s patients, new data show. Findings reveal that the vast majority of adverse events (side effects) reported in…
Over-expressing a fly gene called clueless (clu) can lessen mitochondrial defects in fruit fly models of Parkinson’s disease, a new study reveals. The results also showed that CLUH, the human equivalent of the fly clueless gene, has a similar function, which may pave the way toward new treatment approaches for…
Treatment with oral IPX-203, Amneal Pharmaceuticals’ investigational extended-release carbidopa-levodopa (CD/LD) formulation, reduced “off” time by about 1.5 hours a dose, on average, compared to immediate-release tablets of the medication, according to data from a Phase 3 RISE-PD clinical trial. Top-line results from RISE-PD were announced last year. Detailed…
A surgery-like brain procedure called gamma knife thalamotomy may help to ease tremor in people with Parkinson’s disease, a new study highlights. The study, “Gamma Knife stereotactic radiosurgery as a treatment for essential and parkinsonian tremor: long-term experience,” was published in NeurologÃa. Tremor is one of…
A gene called Fer2 in fruit flies is essential for maintaining the health of dopamine-producing nerve cells and does so by supporting the cells’ mitochondria, which provide them with energy, a study reports. The human equivalent of this gene — a mammalian equivalent, called Nato3, was identified in mice — may…
Some people with Parkinson’s disease have a characteristic genetic signature in a type of immune cell called memory T-cells, a new study suggests. “Parkinson’s disease is not usually seen as an autoimmune disease, but all of our work points toward T cells having a role in the disease,” Cecilia…
A Phase 4 clinical trial called OCEAN is testing whether Ongentys (opicapone), an add-on therapy for “off” periods, can ease pain in people with Parkinson’s disease. The placebo-controlled trial (NCT04986982), which opened in February 2021, is evaluating Ongentys’ effectiveness in up to 140 adults with idiopathic (non-familial)…
Nurses emphasize the importance of developing relationships with Parkinson’s patients in their care and getting to know these people as individuals for effective communication in healthcare settings, a study from Australia reports. The study, “Communication strategies used by Parkinson’s nurse specialists during healthcare interactions: A qualitative descriptive study,” was published…
People who consume more coffee and fish are less likely to develop Parkinson’s disease, according to a new study from Italy. Results also indicate that exposure to agricultural chemicals may increase the risk of Parkinson’s. The study, “Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson’s…
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