Note: This article was updated Aug. 9, 2024, to correct that the improvement seen in good on time in additional analyses was 1.5 hours per dose. The U.S. Food and Drug Administration (FDA) has approved IPX203, a novel extended-release formulation of levodopa and carbidopa, for Parkinson’s disease.
Nearly 13% of people with Parkinson’s disease in North America carry a Parkinson’s-associated genetic mutation, according to new data from the PD GENEration study. This suggests that genetic variants with a link to Parkinson’s are more common than previously thought. “The positivity rate and the high interest in…
Lowering the levels of healthy alpha-synuclein, which is naturally found in the brain, helped to suppress the spread of this protein’s toxic clumps in the brains of a mouse model of Parkinson’s disease, a study reports. The study, “Effects of local reduction of endogenous α-synuclein using…
A test to detect clumping alpha-synuclein protein in the blood — a hallmark of Parkinson’s disease — may help to diagnose the neurodegenerative condition and could also provide insight into how long an individual has been living with Parkinson’s, a new study reports. The study confirmed that the…
Measuring levels of lipids (fat molecules) in the blood may help predict the severity of symptoms in Parkinson’s disease, a new study suggests. The study, “Prediction of motor and non-motor Parkinson’s disease symptoms using serum lipidomics and machine learning: a 2-year study,” was published in npj…
Blocking the activity of a protein called activin A was shown to prevent the development of levodopa-induced dyskinesia in a mouse model of Parkinson’s disease in a recent study. “By prohibiting the protein from functioning, we were able to halt the development of dyskinesia symptoms in the mouse…
Researchers have developed an implantable device, dubbed ImPULS, that can stimulate brain cells using high-frequency sound waves, or ultrasound, in mice. The researchers said they hope the device may be useful for deep brain stimulation in people with disorders such as Parkinson’s disease and as a research tool to…
In a first-of-its-kind development, a team of scientists created a lab model of the blood-brain barrier (BBB) surrounding the brain. The new model represents “a game-changing technology with broad implications for neuroscience, drug discovery, and personalized medicine,” Ziyuan Guo, PhD, assistant professor at the University of Cincinnati department of pediatrics…
Participating in a weekly dance class may not only help people with Parkinson’s disease improve their mobility, but also can be an important source of joy that helps patients feel closer to their loved ones. That’s according to a new study from Sweden that investigated the impact of the…
People with Parkinson’s disease who have clinically significant anxiety tend to walk more slowly and with shorter steps than people with the disease who don’t have anxiety. That’s according to the study, “The impact of anxiety on gait impairments in Parkinson’s disease: insights from sensor-based gait analysis,” which…
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