Marisa Wexler, MS, senior science writer —

The U.K. Medicines and Healthcare products Regulatory Agency (MHRA) has given Mission Therapeutics clearance to launch a Phase 1 clinical trial testing MTX325, its experimental oral therapy for Parkinson’s disease. “The MHRA’s authorisation marks a major step forward in our mission to develop MTX325 as a disease-modifying therapy for…

Nanoplastics — very tiny particles found in the environment when plastic breaks down — that reach a person’s brain can increase the risk of Parkinson’s disease or its progression by prompting the protein alpha-synuclein to clump and turn toxic. “A recent study found that polystyrene plastic pollution, among a…

One month of a high-dose nicotinamide riboside (NR) supplement — thought to boost energy production in the body’s cells — was well-tolerated and eased motor symptoms among people with Parkinson’s disease in a small clinical trial. But the researchers caution that these results are preliminary, and note that data…

Scientists have developed a handheld device that can be used to measure levels of biomarkers for Parkinson’s disease and other neurological disorders. “This portable diagnostic system would allow testing at-home and at point of care, like clinics and nursing homes, for neurodegenerative diseases globally,” Ratnesh Lal, PhD, said in…

When an advanced treatment for Parkinson’s disease such as deep brain stimulation (DBS) stops working, changing treatments or adding a new treatment often can help control disease symptoms, a new study reports. “Based on the results of our study, we can now make a clear recommendation for action. If…

ATH434, an experimental therapy that’s currently in clinical trials for a type of atypical parkinsonism known as multiple system atrophy (MSA), has antioxidant activities that may protect mitochondria and contribute to its therapeutic effects. Data supporting its actions were presented this month at the Society for Neuroscience in Washington,…

Scientists in India are conducting a clinical trial to test whether regularly participating in yoga can slow the progression of Parkinson’s disease. The study, which has been running since early 2022, is ongoing with researchers expecting to continue enrolling new patients into the first few months of 2024. The…

An implanted device that delivers electrical stimulation to nerve cells in the spine helped reduce gait freezing in a man with Parkinson’s disease, improving his ability to walk. Gait freezing occurs when a person stops walking without meaning to, which can lead to falls. The device’s development was described…

Compounds extracted from marigold flowers may be useful in treating Parkinson’s disease, according to a study done in laboratory models. The study, “Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson’s disease,” was published in Food…

Swallowing problems can cause deadly complications for people with Parkinson’s disease, if not handled appropriately, making it critical that hospital clinicians partner with caregivers to help address the needs of patients. That’s the argument made by Annie Brooks, director of strategic initiatives at the Parkinson’s Foundation, in “Dysphagia…