A daily dose of CPL’36, an oral small molecule in the pipeline of Celon Pharma, may ease symptoms for patients who experience levodopa-induced dyskinesia, or uncontrolled movements as a side effect of the mainstay Parkinson’s disease treatment, within one week. That’s according to data from a Phase 2 clinical…
Inserting a piece of nerve tissue from a patient’s ankle into the brain during deep brain stimulation (DBS) surgery appears a safe and feasible way to support damaged dopaminergic neurons in Parkinson’s disease, with the goal of slowing symptom progression. That’s according to results from a Phase 1…
Men with Parkinson’s disease mount stronger and more frequent immune responses than do women against PINK1, a protein that protects nerve cells from death, a new U.S. study found. These findings offer new clues for how the immune system shapes the course of disease in men and women, the…
Thirteen blood biomarkers, including three never previously linked to Parkinson’s disease, may help in diagnosing people sooner and scientists in better understanding the condition, according to a study based on data from nearly 400,000 people. “We identified several blood biomarkers that may be associated with the risk of developing…
A compound formed by nerve cells as they break down cholesterol appears to be involved in the formation of toxic alpha-synuclein protein clumps in the brain — clumps, or aggregates, that are tied to Parkinson’s disease — making this byproduct a potential therapeutic target, a new study in patients…
Male and female mice show different responses to toxic alpha-synuclein clumps, a hallmark of Parkinson’s disease, with males experiencing faster and more aggressive neurodegeneration and females showing earlier brain damage before motor symptoms appear, a study has found. Understanding these sex differences could help develop better, more personalized…
A global team of researchers has identified the molecular switch in a protein complex that regulates how cellular waste disposal mechanisms clean up and recycle unwanted materials — like the toxic alpha-synuclein protein clumps, or aggregates, that drive the death of nerve cells in Parkinson’s disease, according to a…
Newronika plans to use the 13.6 million euros (about $14.3 million) raised in a funding round to support what could be a pivotal clinical trial of its adaptive deep brain stimulation (DBS) system, designed to adjust treatment in real time to better control the symptoms of Parkinson’s disease…
People with chronic kidney disease, a condition characterized by a progressive loss of kidney function, have alpha-synuclein protein deposits in their kidneys, a study in China has found. Alpha-synuclein is a key marker of Parkinson’s disease, suggesting a possible link between kidney function and the neurodegenerative condition. “These findings are…
A large proportion of people with Parkinson’s disease struggle with sleep problems, including issues with falling asleep or maintaining uninterrupted sleep, according to a large study out of Maynooth University in Ireland. Certain factors, such as being male or receiving a Parkinson’s diagnosis at a younger age, may…
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