Joana Fernandes, PhD,  —

Researchers developed a method for noninvasive deep brain stimulation (DBS) that showed promise as a potential way to stimulate neurons without requiring surgery, a new study says. The method works by inducing electrical currents with different high frequencies. When these currents meet deep in the brain, they generate enough stimulation…

Results from a Phase 1/2a clinical trial (NCT01734733) show that treatment with Living Cell Technologies Limited (LCT)’s product NTCELL may be an effective and safe option for patients with Parkinson’s disease. The study investigated the effectiveness and safety of implanting 40 NTCELL capsules into one side of…

Acadia Pharmaceuticals‘ Nuplazid (pimavanserin) is a reliable treatment to manage hallucinations and delusions associated with Parkinson’s disease psychosis (PDP), but its high cost and restricted access may limit its use in clinical practice, a new study says. The review, “Pimavanserin: A Novel Antipsychotic for Parkinson’s Disease Psychosis,”…

Treatment with ADS-5102 (amantadine) significantly decreased levodopa-induced dyskinesia and off-time episodes in patients with Parkinson’s disease at three months, and maintained those benefits for another three months, according to results of a Phase 3  clinical trial that may prove pivotal in the medicine’s approval. Adamas Pharmaceuticals, the treatment’s developer, has filed a New Drug Application…

Researchers found that clumps of faulty protein involved in Alzheimer’s, Parkinson’s, and Huntington’s disease cause brain damage by invading and rupturing small vesicles in neurons. The study, “Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins,” published in the journal Acta Neuropathologica, bring…

Researchers have found new biomarkers that may improve the ability of clinicians to predict which patients in the early stages of Parkinson’s disease will suffer cognitive impairment within the first three years of their diagnosis, a new study says. These biomarkers include deficits in dopaminergic circuits (neurons that produce dopamine, which…

Parkinson’s disease and amyotrophic lateral sclerosis (ALS) may have more in common than previously thought. According to a recent study, a known ALS gene called SOD1 also may be involved in the development of Parkinson’s. This finding opens the possibility of treating Parkinson’s patients with therapies targeting SOD1 toxicity, which already have…

Israel’s NeuroDerm will update its ND0612H and ND0701 therapies for Parkinson’s disease during the 21st International Congress of Parkinson’s Disease and Movement Disorders, scheduled for June 4-8 in Vancouver. ND0612H is a liquid formulation of levodopa/carbidopa (LD/CD) given subcutaneously to patients with advanced Parkinson’s. Trial 006 (NCT02577523) enrolled…

Acorda Therapeutics will soon release novel data on its Phase 3 SPAN-PD trial (Study 004, NCT02240030) investigating the experimental drug Inbrija (CVT-301) as a potential therapy for patients with Parkinson’s disease. Acorda presents its poster, “Inhaled levodopa (CVT-301, 84-mg dose) significantly improves motor function during OFF periods in Parkinson’s disease…

People with Parkinson’s disease and related dementias are more likely to die younger than those of comparable age in the general population, often of ills linked to their neurological disease or of cardiovascular problems, a recent study by the Mayo Clinic found. Specifically, Parkinson’s patients…