Author Archives: Forest Ray PhD

New Method Shows How Alpha-synuclein Can Damage Mitochondria

A new technique shows that alpha-synuclein, the protein at the heart of Parkinson’s disease, affects cell membranes differently, based on their composition. This discovery sheds light on how alpha-synuclein clumps known as amyloids might disrupt cellular membranes, potentially helping to design therapies that might slow or stop…

Parkinson’s Foundation Shares Early Results of PD GENEration Study

Preliminary results from the PD GENEration study demonstrate that comprehensive genetic testing and counseling, and the identification of rare genetic mutations linked to Parkinson’s disease, is feasible for the Parkinson’s community at large. Launched in 2019 through the Parkinson’s Foundation and supported partly by Biogen, the study…

OWEAR Opens Software and Datasets to Promote Technology in Research

The Open Wearables Initiative (OWEAR) is making public its software and database for wearable sensors and other related-health technologies to assist clinical research, Shimmer Research announced. “We are proud to announce the release of the OWEAR database, which includes the organization’s initial index of open source software and datasets, together…

COVID-19 Exacerbates Some Parkinson’s Symptoms, Study Finds

COVID-19 infection appears to worsen some symptoms of Parkinson’s disease, requiring adjustments to therapy, according to a recent case study. The study, “Effects of COVID-19 on Parkinson’s disease clinical features: a community-based case-control study,”  was published in the journal Movement Disorders. SARS-CoV-2, the strain of coronavirus…

APOE Variant Directly Tied to Lewy Body Dementias in 2 Studies

A variant of the apolipoprotein (APOE) protein, called APOE4, has been shown to directly affect Lewy body dementias, such as Parkinson’s disease. Two separate studies, published simultaneously, found that APOE4 directly regulates levels of alpha-synuclein, which clumps  to form the nerve-damaging Lewy…

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