People with neurodegenerative diseases like Parkinson’s disease or dementia are more vulnerable to heat-related complications than those without these conditions, according to a commentary by two neurologists. Medical providers should be trained to understand how heat waves can affect these people, the viewpoint advised. It was co-written by Indu…
Adaptive deep brain stimulation (aDBS) resulted in long-lasting relief from bradykinesia and walking difficulties in a 61-year-old Parkinson’s disease patient, whose quality of life also improved, researchers wrote in a case report about the man. Unlike conventional DBS (cDBS), where electric brain stimulation is constant or adjusted manually…
In people with Parkinson’s disease, shrinkage in tremor-related brain areas is associated with the progression of motor symptoms, according to a study. In the brain’s gray matter, which contains cell bodies of neurons, this shrinkage, or atrophy, of tremor-related regions and the whole brain over two years was associated…
Having foot pain, particularly of mild intensity or occasional pain, is associated with a higher risk of falls among people with Parkinson’s disease, a study in Spain shows. The study assessed the factors that could contribute to a higher risk of falls with Parkinson’s and found that people with…
A consortium dubbed Center Without Walls is planning to begin human testing of specific positron emission tomography (PET) radiotracers, which its scientists identified, to detect toxic proteins like alpha-synuclein, helping diagnose and monitor Parkinson’s and similar diseases. Funded by a five-year, $30 million grant from the National Institutes of…
A flexible dose of experimental oral treatment tavapadon significantly lessened motor symptoms in adults with early-stage Parkinson’s disease, according to top-line results from a completed Phase 3 clinical trial. Developer Abbvie expects to present full results of the study, TEMPO-2 (NCT04223193), at a future medical meeting and…
P2B001, Pharma Two B’s investigational combination therapy of pramipexole and rasagiline, safely and effectively lessens symptoms in people with early-stage Parkinson’s disease, according to pooled data from Phase 2b and Phase 3 clinical trials. The combo treatment was also found to be as effective as titrated extended-release pramipexole…
Axons, nerve cell projections that carry electrical signals from one cell to another, may look more like pearls on a string than the cylindrical tubes they are commonly believed to resemble, according to a study, which demonstrated that interfering with the formation of pearl-like structures impaired the transmission of electric…
Supervised exercises at home may safely improve motor function and quality of life in people with mild to moderate Parkinson’s disease, a study in China suggests. The benefits were seen both with sessions conducted by a physical therapist at patients’ homes and with telerehabilitation using an application with predetermined…
A clinical trial testing the safety and tolerability of Brenig Therapeutics‘ BT-267, a potential disease-modifying therapy for Parkinson’s due to an unknown cause — known as idiopathic — or disease associated with LRRK2 gene mutations, has begun dosing healthy volunteers. Following this initial assessment — the first-in-human trial of…
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