Researchers developed “mini-brains” — midbrain-like organoids — that recapitulate for a first time two key Parkinson’s hallmarks in that organ: the formation of toxic protein clumps known as Lewy bodies and the loss of dopamine-producing neurons. A combination of two known Parkinson’s risk factors — a deficiency of the beta-glucocerebrosidase…
Researchers have developed a new way to make miniature 3D versions of the brain by using human stem cells. These new “mini-brains” will allow scientists to observe brain development, test promising new therapies, and study neurological diseases such as Parkinson’s disease. Findings were published in the study, “Induction of…
Researchers at the Johns Hopkins Bloomberg School of Public Health have developed “mini-brains” that may present a more accurate and effective way of testing new drugs for many neurological disorders, such as Parkinson’s disease. These human cell-derived structures, which represent an existing new alternative to animal testing, were recently discussed in…
In a recently published paper in Tissue Engineering Part C: Methods entitled “3D Neural Spheroid Culture: An In Vitro Model for Cortical Studies“, researchers from Brown University reported a method to produce spheres like mini-brains containing central nervous system tissue. These mini-brains have no…
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