Cyrano Therapeutics is supporting an investigator-initiated clinical study that will evaluate CYR-064, its leading nasal candidate therapy, to restore smell loss in Parkinson’s disease. The study, led by neurologist David Silvers, MD, in Palm Beach Gardens in Florida, seeks to enroll 15 to 20 adults, ages 18-80, with…

Since my diagnosis of Parkinson’s disease in 2015, my sense of smell has been nonexistent. Overall, I have to say the loss hasn’t bothered me too much, especially when compared with other Parkinson’s symptoms, such as tremor, slowness, and stiffness. The only time it does bother me is…

ATH434, Alterity Therapeutics’ experimental oral therapy, prevented a loss in the sense of smell — an early and common symptom of Parkinson’s disease — in a mouse model, and helped to preserve nerve cells and restore motor skills in older animals, a study showed. These findings add to those…

People with REM sleep behavior disorder (RBD) — an early nonmotor symptom of Parkinson’s disease — were significantly more likely than others to wrongly think their sense of smell was normal when olfactory deficits were evident, a small study found. Parkinson’s patients with RBD also had a diminished sense…

My sister Bev, who has stage 3 Parkinson’s disease (PD), is delighted when the spring equinox arrives in Ohio, where she lives. Gone for the most part are the blustery winter storms and frigid temps. Appearing are the fragrant floral blossoms and the season of smells on the outdoor…

A protein present in the SARS-CoV-2 virus — the virus that causes COVID-19 — is able to interact with alpha-synuclein and speed the formation of amyloid fibrils, the toxic clumps that trigger nerve cells death and are a hallmark of Parkinson’s disease, a study has shown. “We show, in…

We encounter signs almost every day of our lives. Traffic lights tell us when to stop or go, and road signs tell us which exit to take. Turn signals (when used) let us know if the car in front of us is turning left or right. Dark clouds in the…

A chemical sense related to smell, called the trigeminal system, may help researchers understand which people who lose their sense of smell will later develop Parkinson’s disease. Parkinson Canada is supporting this research through a $45,000, yearlong grant, given to Johannes Frasnelli, PhD, of l’Université de Québec á…

Prolonged, low-level inhalation of the common weed-killer paraquat, implicated in the risk of Parkinson’s disease, caused male mice to lose at least some of their sense of smell, a study reports. This work also supported previous studies showing the inhaled chemical enters the brain via the olfactory nerve.

Inhaled bacterial toxins can cause inflammation in a brain region associated with smell, and this inflammation may help in the initiation and propagation of Parkinson’s-related molecular changes in the brain, a study in mice suggests. The study, “IL‐1β/IL‐1R1 Signaling Induced by Intranasal Lipopolysaccharide Infusion Regulates Alpha‐Synuclein…