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May 17, 2021 News by Marta Figueiredo, PhD

Scientists Shed Light on Workings of Mutant Alpha-synuclein Protein

A mutant form of the alpha-synuclein protein — associated with early onset, severe familial Parkinson’s disease — recruits its normal version to propagate the toxic clumps that lead to neurodegeneration, a study in mice has found. The data, specific for the E46K mutant version of alpha-synuclein, suggest that…

October 15, 2019 News by Alice Melão

Mutations in Alpha-Synuclein Speed Protein Clumping in Familial Parkinson’s and Affect Severity, Study Finds

A detailed analysis of alpha-synuclein — a key protein involved in Parkinson’s — revealed how variants of this protein change over time, allowing researchers to identify the initial stages of protein aggregation involved in early onset disease. These findings provide new insights into how genetic mutations — especially…

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