Common Parkinson’s Mutation Tied to Neuron Damage via Calcium Imbalance in Study

The most common mutation associated with Parkinson’s disease — called LRRK2-G2019S — results in abnormal global protein production that increases the levels of calcium within dopamine-producing neurons, likely making them more vulnerable to degeneration, a study suggests. “Mapping out this progression of events is an important advancement in…

Blood Pressure Medicine Dynacirc Falls Short in Phase 3 Trial for Early Parkinson’s

Long-term use of blood pressure medication Dynacirc (isradipine) does not slow disease progression in people with early Parkinson’s disease, according to findings from a Phase 3 clinical trial. These results contrast with what was previously observed in mice, in which the medication eased damage to dopaminergic…