A novel determinant for Parkinson’s Disease as been discovered: a previously unknown defect in the function of the Pla2g6 protein leads to calcium homeostasis disruption and neuronal cell death. The research paper, entitled “Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease,” was published in Nature Communications. While…
News
A drug typically prescribed for dementia may help prevent debilitating falls in people with Parkinson’s disease, according to a study, “Rivastigmine for gait stability in patients with Parkinson’s disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial,” published in the journal The Lancet Neurology. Falls are a frequent…
An analysis from business intelligence provider GBI Research titled “Frontier Pharma: Parkinson’s Disease — Identifying and Commercializing First-in-Class Innovation,” claims the current Parkinson’s disease (PD) treatment market relies on neuromodulators, and even though symptoms might be soothed, no neuromodulator has demonstrated neuroprotective properties to prevent or even slow…
A recent study published in JAMA Neurology suggested an association between weight loss in patients with early Parkinson’s disease and rapid disease progression. Weight loss is usual in patients with Parkinson’s disease (PD), but these new findings indicate that weight loss early in the disease’s progression reflects a more serious form…
Cynapsus Therapeutics, Inc., a Toronto-based specialty pharmaceutical company, and The Michael J. Fox Foundation for Parkinson’s Research (MJFF) announced they are collaborating to incorporate wearable device technology and “big data” approaches into Cynapsus’ pivotal Phase 3 clinical study of APL-130277, a fast-dissolving, sublingual formulation of the drug apomorphine to treat…
A recent article in the Harvard Gazette suggests dance as a potential treatment for neurodegenerative disorders such as Parkinson’s disease (PD). Imaging studies have identified several brain regions involved in the complex, rhythmical, and coordinated movements that constitute dance. The motor cortex is — as with other kinds of voluntary…
A new study from the German Center for Neurodegenerative Diseases, published in the journal BRAIN, sheds new light on the processes leading to aggregation of the protein αlpha-synuclein in the brain of patients with Parkinson’s disease (PD). It has been proposed that the aggregates propagate in a fashion similar to prions,…
Contrary to recent evidence, new research has found no positive correlation between anticholinergic medication intake and a higher risk for dementia in Parkinson’s disease (PD) patients. The study is titled “Anticholinergic Load: Is there a Cognitive Cost in Early Parkinson’s Disease?” and appears in the Journal…
Evidence has shown a potential connection between chronic hepatitis C virus (HCV) infection and neurological and psychiatric disorders such as Parkinson’s disease (PD). In a recent study, investigators sought to determine if the disease was, in fact, a significant risk factor for Parkinson’s development. Their findings, in a study…
A recent study shows that patients with Parkinson’s disease (PD) have a dysfunctional brain reward anticipation response — a finding likely linked to the decreased motivational state that can afflict PD patients. The deficit in dopaminergic signaling that underlies PD affects more than just motor skills. Depression, apathy, and sleep disorders also frequently…
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