Scientists have identified a new strategy to attenuate one of the side effects — uncontrolled movement — caused by levodopa, the most effective treatment in the management of Parkinson’s disease symptoms. The study, entitled “M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia,” was published…
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Plant-produced flavonoids may help ward off Parkinson’s disease according to a new article from researchers in Malaysia and Australia. The report, titled “Protective Mechanisms of Flavonoids in Parkinson’s Disease,” appeared in the journal Oxidative Medicine and Cellular Longevity. Parkinson’s disease is a progressive neurological disorder in which dopamine cells…
Boston University School of Medicine and Northeastern University researchers have proposed a molecular mechanism by which only certain mutations in human apoA-1 protein cause familial amyloidosis while others do not. The research paper, entitled “Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the…
The Van Andel Research Institute (VARI) has announced the expansion of its neurodegenerative disease research program, with Dr. Gerhard Coetzee and Dr. Viviane Labrie joining its Center for Neurodegenerative Science. The center’s focus is the development of new therapies for brain repair, the discovery of biomarkers, and the study of the molecular,…
A team of specialists working for the International Parkinson and Movement Disorder Society (MDS) have developed a novel tool for healthcare professionals that could have a significant impact in Parkinson’s disease (PD) diagnosis and treatment, particularly in its early stages. It also may benefit disease research. The development of the tool, actually a set of…
At the first Spark Summit Europe, a presentation by Intel researchers in cooperation with the Michael J. Fox Foundation proposed that Big Data could be the key to unlocking the mysteries of Parkinson’s disease. Summit Europe is the premier event bringing together the community known as Apache Spark, a…
As part of its National Family Caregivers Month effort, the Parkinson’s Disease Foundation (PDF) a research, education and advocacy organization, is offering free resources to address the unmet needs of care partners of people living with Parkinson’s disease. PDF is inviting Parkinson’s disease care partners and loved ones to access…
A currently enrolling clinical study observing Parkinson’s disease patients seeks to determine if those with the disease can benefit from the potential power of stem cells. The study, “Outcomes Data of Adipose Stem Cells to Treat Parkinson’s Disease,” is currently recruiting participants, and clinicians have begun to administer the investigative…
When most people think about Parkinson’s disease (PD), they focus on movement problems almost exclusively. But mild cognitive impairment is among other potential disease symptoms, although medical professionals and researchers currently disagree on the extent and exact nature of this problem in Parkinson’s patients. Progressive tremors and rigidity occur in PD largely due to the…
Lund University researchers have shown that cerebrospinal fluid (CSF) biomarkers of angiogenesis are raised in Parkinson’s disease (PD) patients and are related to walking and balance difficulties, blood-brain barrier (BBB) increased permeability, and white matter lesions (WMLs). The research study, entitled “Increased CSF biomarkers of angiogenesis in Parkinson Disease”…
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