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Therapies intending to increase dopamine levels in the brains of Parkinson’s patients have struggled to adequately regulate signaling. But researchers have now engineered transplant dopamine neurons that might be switched on or off using designer drugs — suggesting these transplants might be a viable way of treating Parkinson’s via dopamine release after…

University of Texas Health Science Center researchers have identified physiologic changes in dopamine neurons in a key animal model of Parkinson’s known to display disease symptoms, the MitoPark mouse model. The dopamine changes in the mice, however, clearly came before any symptoms appeared — findings that may lead to earlier identification of  Parkinson’s in people,…

An innovative new motion monitoring tool that resembles a wristwatch could soon improve quality of life and treatment effectiveness for people with Parkinson’s disease by better informing the neurologists who are treating them. A research team at Cedars-Sinai medical center in Los Angeles, California, is one…

Important findings linking the protein Connexin 36 with the disrupted communication between nerve cells in Parkinson’s patients may contribute to a better understanding of the disease. The study was developed by Bettina Schwab, a former Ph.D. student at The Netherlands’ University of Twente Faculty of Electrical Engineering, Mathematics, and Computer…

Acorda Therapeutics recently presented results from a Phase 2b study of its investigational drug CVT-301 in patients with Parkinson’s disease (PD) at the 68th Annual Meeting of the American Academy of Neurology in Vancouver, Canada. “Approximately 350,000 people with PD in the U.S. experience OFF periods, which can be very disruptive. There…

Coffee is one of the most consumed drinks in the world, with U.S. consumers spending an average of $40 billion on coffee per year. Its main component, caffeine, is a natural stimulant that has been long considered the fuel behind modern society’s workforce, with many relying on multiple cups of coffee…

A University of California, San Diego, study shows that the same brain system involved in a sudden stop in physical movement also interrupts cognitive processes. The findings hold implications for Parkinson’s disease, where cognitive impairment is a major symptom. The study, “Surprise disrupts cognition via a fronto-basal ganglia…

Researchers found a genetic variation, known as the GG genotype, that identifies those Parkinson’s disease (PD) patients more likely to have slower disease progression — evidenced through tremors — and lower levels of alpha-synuclein, a protein linked to the disease. The findings have implications in disease diagnosis and treatment strategies, and were recently presented…

A European patent has been issued covering the composition of matter for Aeolus Pharmaceuticals’ AEOL 11114, an oral Parkinson’s disease (PD) drug. A patent for AEOL 11114 has also been allowed in Japan. AEOL 11114 was created by Brian J. Day, Ph.D., of National Jewish Health, and Manisha Patel, Ph.D.,…

Cynapsus Therapeutics and MonoSol Rx announced that they have signed a global licensing agreement for select intellectual property, including existing and future patents and patent applications, covering all oral films containing apomorphine for the treatment of “off” episodes  in patients with Parkinson’s disease (PD). According to the Michael J. Fox Foundation for…