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Molecule Protected Dopamine Neurons in Mice with Parkinson’s

Administering a naturally occurring growth factor to a mouse model of Parkinson’s disease reduced inflammation and prevented neurons from dying, suggesting that such factors have the potential to stop or slow the progression of disease. The study, “Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations…

Kainos Begins Phase 1 Trial of Therapy for Parkinson’s Disease

The first patient has been dosed in a two-part Phase 1 clinical trial evaluating KM-819, Kainos Medicine’s potential disease-modifying treatment for Parkinson’s disease (PD), the company announced in a press release. The dose-escalation clinical trial (NCT03022799) will evaluate the drug’s safety, tolerability, and biochemical properties following single…

More than 300 Genes Impact Toxicity of Protein Linked to Brain Function, Study Finds

Researchers have identified more than 300 genes that influence alpha-synuclein’s toxicity, and among them are many known to predispose individuals to Parkinson’s disease (PD), researchers said. The finding provides new insight into what mechanisms lead to the disease. The hallmark of Parkinson’s disease is the formation of alpha-synuclein protein aggregates, which…