News

Adamas to Give Presentations on Treatment for Involuntary Muscle Movements in Parkinson’s

Adamas Pharmaceuticals will make two presentations in Boston this month on ADS-5102 as a treatment for involuntary muscle movements associated with Parkinson’s disease. ADS-5102, a high-dose amantadine therapy, decreases the duration, intensity and debility of the muscle movements, clinical trials have shown. The problems, which range from slight hand tremors to uncontrollable upper…

MJFF Grant Will Support Mission Therapeutics’ Test of Novel USP30 Therapy in Parkinson’s Models

British pharmaceutical firm Mission Therapeutics will test its potent, selective USP30-targeted inhibitors in stem cell-derived Parkinson’s disease models, as part of research funded by the Michael J. Fox Foundation for Parkinson’s Research (MJFF). Cells maintain healthy mitochondria — the cell’s power generators — by degrading damaged mitochondria in a process known as mitophagy. Defective…

Tiny Changes in Alpha-synuclein Protein Could Be an Important Driver in Parkinson’s, Study Suggests

Researchers have found that selective mutations in the protein alpha-synuclein affect its binding to cell membranes with potential implications in Parkinson’s disease (PD) and therapeutic strategies. The study, “Alpha-Synuclein Disease Mutations Are Structurally Defective and Locally Affect Membrane Binding,” was published in the Journal of the American Chemical Society.

Anavex Therapies Reverse Cognitive Defects in Mice, Suggesting Their Use for Parkinson’s

Anavex Life Sciences therapies reversed Alzheimer’s-related cognitive deficits in mice and improved processes connected with the disease, according to presentations at an international conference on Alzheimer’s and Parkinson’s. The presentations at the 13th International Conference on Alzheimer’s & Parkinson’s Diseases dealt with the experimental treatments Anavex 2-73, Anavex 3-71, and Anavex…