Computer algorithms used to analyze large medical databases found an early diagnosis of walking difficulties or tremors best predicted a future diagnosis of Parkinson’s disease, a study found. The study, “Accelerating diagnosis of Parkinson’s disease through…
A review of current literature by Parkinson’s disease researchers worldwide found studies that attempted to classify the disease into a limited number of subtypes fall short in both methods and clinical applications. New approaches are needed in re-evaluating Parkinson’s disease subtypes, and should include those…
A new model of alpha-synuclein in Parkinson’s development, addressing both where aggregates first appear and their spread through the nervous system, may explain the variety of early symptoms, asymmetry in motor symptoms, and variability of disease progression seen in patients, a study reported. The study,…
Dose-dependent decreases in targeted fatty acids were seen with YTX-7739, an investigational therapy for Parkinson’s disease, suggesting the medicine engages its therapeutic target, according to the results of a Phase 1a multiple-ascending dose study in healthy volunteers.
Microbleeds found in the brains of people with Parkinson’s disease by magnetic resonance imaging (MRI) scans were associated with cognitive decline, a study demonstrated. Higher levels of a microbleed-associated biomarker also were found in patients with dementia. Moreover, a statistical analysis found the…
Gocovri (amantadine) more than doubled the daily time on levodopa-based therapies without any dyskinesia — involuntary, uncontrolled movements — in people with Parkinson’s disease compared to those given a placebo, an analysis of data from two Phase…
In light of Parkinson’s Awareness Month — starting April 1st — Parkinson Canada is calling for better awareness of the neurodegenerative disorder, while supporting organizations dedicated to helping those impacted by it. This message is made more urgent by COVID-19, according to…
Several microRNAs in the blood of people with Parkinson’s disease differ from healthy controls, correlate with disease progression, and are associated with hallmarks of the disorder, a large-scale study reported. These findings support the possible use of microRNAs as biomarkers in…
Transplanting dopamine-producing nerve cells grown from monkeys’ own cells back into their brains relieved motor and depression symptoms associated with Parkinson’s disease, a study demonstrated. This approach avoided transplant-associated tissue rejection and supports further research as a treatment option for people…
The impact of deep brain stimulation (DBS) in improving motor function in people with Parkinson’s disease may be related to a patient’s response to levodopa therapy, and to the type of DBS administered, according to a small study. Patients who responded to levodopa demonstrated better…
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