More people with Parkinson’s disease than previously estimated experience pseudobulbar affect, and its emotional outbursts can be especially common in patients with depression, a study in patients at a single U.S. institution reported. “Our data suggest that the prevalence of PBA [pseudobulbar affect] is possibly higher in the PD…
Gout does not increase the risk of developing Parkinson’s disease, according to an analysis based on insurance data in Korea. The analysis indicates, however, that people who have had a stroke and those with high blood pressure might have a higher Parkinson’s risk. Results were published in the study “…
Although some previous research has indicated that certain variations in the FGF20 gene increase the risk of Parkinson’s disease, a new Chinese study indicates that these mutations don’t increase Parkinson’s risk. The study, “Quantitative assessment of the effect of FGF20 rs1721100 and rs12720208 variant on the…
A new clinical trial is testing a novel noninvasive brain stimulation technology developed by Highland Instruments in people with Parkinson’s disease who have postural instability — difficulty with balance and the reflexes that help a person to stand upright. The trial (NCT03981055), which is funded by the National…
Nearly all participants in the SPARK clinical trial had evidence of abnormal dopamine activity on a brain scan known as DaT-SPECT, for dopamine transporter single-photon emission computed tomography, according to a new study. Thus, these results suggest that DaT-SPECT — sometimes used as a biomarker in recruiting participants for clinical…
The Parkinson’s Progression Markers Initiative (PPMI) is expanding to enroll up to 100,000 people with and without Parkinson’s disease through an online portal. This expanded PPMI study (NCT04477785) is particularly seeking to enroll people who were diagnosed with Parkinson’s in the past two years and are not…
People with the most common form of arthritis, osteoarthritis, may be at increased risk of developing Parkinson’s disease, according to a study from the U.K. This result is in line with an earlier study from Taiwan. Based on these findings, “measures aiming at the prevention of Parkinson’s disease should be…
Because people with Parkinson’s disease tend to take shorter steps and move more slowly, they get less of a “pendulum-like” effect helping their movements, which makes their gait less efficient and ultimately uses more energy, a small study suggests. Its findings also indicate that Nordic walking — walking with…
People with early- or late-onset Parkinson’s disease tend to have different characteristic changes in their speech, according to a new study. The study, “Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease,” was published recently in npj Parkinson’s Disease. As many as nine in…
Mitochondrial dysfunction in dopamine-producing brain cells is sufficient to cause Parkinson’s disease, according to a new study done in mice. The study, “Disruption of mitochondrial complex I induces progressive parkinsonism,” was published in Nature. Parkinson’s is caused by the death and dysfunction of dopamine-producing (dopaminergic) neurons.
Get regular updates to your inbox.
