Over-expressing a fly gene called clueless (clu) can lessen mitochondrial defects in fruit fly models of Parkinson’s disease, a new study reveals. The results also showed that CLUH, the human equivalent of the fly clueless gene, has a similar function, which may pave the way toward new treatment approaches for…
Treatment with oral IPX-203, Amneal Pharmaceuticals’ investigational extended-release carbidopa-levodopa (CD/LD) formulation, reduced “off” time by about 1.5 hours a dose, on average, compared to immediate-release tablets of the medication, according to data from a Phase 3 RISE-PD clinical trial. Top-line results from RISE-PD were announced last year. Detailed…
A surgery-like brain procedure called gamma knife thalamotomy may help to ease tremor in people with Parkinson’s disease, a new study highlights. The study, “Gamma Knife stereotactic radiosurgery as a treatment for essential and parkinsonian tremor: long-term experience,” was published in NeurologÃa. Tremor is one of…
A gene called Fer2 in fruit flies is essential for maintaining the health of dopamine-producing nerve cells and does so by supporting the cells’ mitochondria, which provide them with energy, a study reports. The human equivalent of this gene — a mammalian equivalent, called Nato3, was identified in mice — may…
Some people with Parkinson’s disease have a characteristic genetic signature in a type of immune cell called memory T-cells, a new study suggests. “Parkinson’s disease is not usually seen as an autoimmune disease, but all of our work points toward T cells having a role in the disease,” Cecilia…
A Phase 4 clinical trial called OCEAN is testing whether Ongentys (opicapone), an add-on therapy for “off” periods, can ease pain in people with Parkinson’s disease. The placebo-controlled trial (NCT04986982), which opened in February 2021, is evaluating Ongentys’ effectiveness in up to 140 adults with idiopathic (non-familial)…
Nurses emphasize the importance of developing relationships with Parkinson’s patients in their care and getting to know these people as individuals for effective communication in healthcare settings, a study from Australia reports. The study, “Communication strategies used by Parkinson’s nurse specialists during healthcare interactions: A qualitative descriptive study,” was published…
People who consume more coffee and fish are less likely to develop Parkinson’s disease, according to a new study from Italy. Results also indicate that exposure to agricultural chemicals may increase the risk of Parkinson’s. The study, “Relationships of Nutritional Factors and Agrochemical Exposure with Parkinson’s…
People with Parkinson’s disease who have arthritis in their knees report minimal improvements in life quality after undergoing knee replacement surgery, a new study reports. “Data from this study suggest that [total knee replacement] has no clinical benefit in improving [quality of life] beyond a slight improvement in pain-related…
A modified version of the Interlocking Finger Test — a bedside screening done by assessing hand movements — could be useful for detecting dementia in people with Parkinson’s disease, a new study indicates. “We recommend the use of the modified test version,” the researchers wrote, noting that “scores…
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