Both a misfolded form of the alpha-synuclein protein and an inflammatory cue are needed to trigger the Lewy bodies that drive the death of dopaminergic neurons in the brains of people with Parkinson’s disease, according to a study in human stem cells. “The results support previous research showing that…
A single dose of CAP-003, a gene therapy being developed by Capsida Biotherapeutic, significantly increased the levels of GCase enzyme in the brains of non-human primates. The enzyme levels reached up to eight times the amount considered necessary to restore normal enzyme activity in individuals with Parkinson’s disease…
App-based consumer technology like Rune Labs’ StrivePD may help people with Parkinson’s disease feel more confident in managing their symptoms, bridging the gap in specialty care by providing continuous monitoring, according to the results of a pilot program done in collaboration with Kaiser Permanente. Patients in the program…
Exposure to air pollutants, such as fine particulate matter and nitrogen dioxide, may increase the risk of developing Parkinson’s disease and dyskinesia, or involuntary movements, according to a study using data from the Rochester Epidemiology Project. These findings add to growing evidence that breathing polluted air is a…
GT-02287, a potential therapy for Parkinson’s disease, showed promising results in a Phase 1 clinical trial involving healthy volunteers, according to data announced by developer Gain Therapeutics. The investigational treatment was found to be safe and well tolerated at doses projected to be effective in people with the neurodegenerative…
Patients treated with bemdaneprocel, a cell therapy that Bluerock Therapeutics is developing for Parkinson’s disease, continue to spend more time with well-controlled symptoms and less time in off periods, when symptoms aren’t adequately controlled despite medication use. That’s according to final data from exPDite (NCT04802733), a completed…
Pramipexole, the active ingredient in the Parkinson’s disease therapy Mirapex, appears to overactivate a brain region known as the external globus pallidus — findings that could explain the poor decision-making and impulse control that occurs as a side effect of the medication in some patients — according to…
Parkin, a protein linked to Parkinson’s disease that’s lost in certain types of cancer, triggers the release of signaling molecules that activate and attract immune cells to fight tumors, according to a study led by researchers at The Wistar Institute in Philadelphia. “Parkin has only recently been implicated for…
Ten consecutive weeks of either high-intensity interval training or continuous training, which is moderate in intensity, effectively eased disease motor symptoms by about 25% and reduced fatigue in adults with Parkinson’s disease taking part in a small study. These findings further emphasize the significance of exercise as a…
Subcutaneous, or under-the-skin, injections of COYA 302, a combination therapy in development by Coya Therapeutics, were found to reduce excessive inflammation and immune cell activation in a mouse model of Parkinson’s disease. These beneficial effects were observed in the nigrostriatal pathway, a brain circuit responsible for motor control,…
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