LRRK2 Gene Mutation Protects Against Infection But Increases Parkinson’s Risk Via Inflammation, Study Suggests
Although it may be protective against infections, a specific mutation in the LRRK2 gene — the gene linked to…
Articles by José Lopes, PhD
Nuplazid Eases Depression in Parkinson’s Patients, Phase 2 Trial Shows
Treatment with Nuplazid (pimavanserin), approved in the U.S. for treating hallucinations and delusions associated with Parkinson’s…
Tavapadon Lessens Motor Symptoms in Patients with Early-stage Parkinson’s, Phase 2 Trial Finds
Oral treatment with tavapadon eased motor symptoms and was well-tolerated by patients with early-stage Parkinson’s, according to…
Accordion Pill Enables Higher Optimal Doses of Levodopa Than Sinemet, Data Show
Patients with Parkinson’s disease who were treated with Accordion Pill Carbidopa/Levodopa (AP-CD/LD) tolerated a higher dose of levodopa and…
Mitsubishi Tanabe Pharma Shares Results from Phase 2 Study of ND0612 for Advanced Parkinson’s
Continuous delivery of carbidopa/levodopa (CD/LD) with ND0612 under the skin led to quick improvement of clinical status and better…
Phase 2 Trial of Gene Therapy, VY-AADC02, for Advanced Parkinson’s Enrolling in US
A Phase 2 clinical trial testing the safety and effectiveness of the gene therapy VY-AADC02 in people with advanced…
‘Exergaming’ on Stationary Bicycle Eased Parkinson’s Motor Problems
Exercising at home with a stationary bicycle — using a motivational app and remote supervision to increase compliance — eases…
Squalamine, Compound in ENT-01 of Parkinson’s Trials, Seen to Aid Aging Gastrointestinal Tract
An antimicrobial compound called squalamine works to ease age-related constipation and gut dysmotility, or problems with how muscles of the…
Michael J. Fox Foundation Funds Search for Parkinson’s Urine Biomarkers
The Michael J. Fox Foundation for Parkinson’s Research (MJFF) is funding work at Tymora Analytical Operations that screens for…
Lewy Bodies Diverse in Structure and Some Fibrils Can Migrate, Study Reports
A detailed analysis of the structure of alpha-synuclein clumps suggests that Parkinson’s is a systemic disease, whose characteristic protein aggregates…