Weight Loss Linked to Worse Outcomes in Parkinson’s Patients, Study Shows

Weight Loss Linked to Worse Outcomes in Parkinson’s Patients, Study Shows

Weight loss in Parkinson’s disease patients increases the risks for dementia and dependency care, and reduces patients’ life expectancy, according to a new study.

These findings suggest that monitoring weight and timely dietary interventions to counteract weight loss may significantly improve the outcome of Parkinson’s disease patients.

The study, “Early weight loss in parkinsonism predicts poor outcomes: Evidence from an incident cohort study,” was published in the journal Neurology.

Researchers at the University of Aberdeen in Scotland followed 515 participants – 187 with Parkinson’s disease, 88 with the so-called atypical parkinsonism, and 240 controls – for a median of five years. During this period they registered patients’ weight and evaluated how weight variations influenced disease outcomes.

Individuals with atypical parkinsonism are characterized by some of the signs and symptoms of Parkinson’s disease – such as tremor, slowness, and walking problems – without having a Parkinson’s disease diagnosis.

“Weight loss is a common problem in Parkinson’s but it wasn’t clear before we did this how common it was, mainly because of biases in previous studies, or what the consequences were of weight loss. Our hypothesis was that people who are losing weight were going to have adverse outcomes,” Dr. Angus Macleod, the study’s lead author, said in a press release.

The results showed that patients with Parkinson’s disease and parkinsonism have, from early on, lower body weights compared to those without the disease, or controls. Further analysis also showed that weight loss occurring within one year of diagnosis was associated with a higher risk of dependency (patients are no longer able to perform daily activities), dementia, and death.

“Our finding that those who lose weight have poorer outcomes is important because reversing weight loss may therefore improve outcomes,” Macleod said. “Therefore, it is vital that further research investigate whether e.g. high calorie diets will improve outcomes in people with Parkinson’s who lose weight.”

“While other studies have demonstrated that weight loss is common in Parkinson’s, this is the first to consider the impact this symptom may have,” said Prof. David Dexter, deputy director of research at Parkinson’s UK, a charity that contributed funding for the research.

“It has yet to be determined whether this quicker progression can be corrected by supplementation with a high calorie diet, however this could be a key potential development,” Dexter added.

Patricia holds a Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She has also served as a PhD student research assistant at the Department of Microbiology & Immunology, Columbia University, New York.
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Patricia holds a Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She has also served as a PhD student research assistant at the Department of Microbiology & Immunology, Columbia University, New York.
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5 comments

  1. Laura Mahony says:

    Is it possible that the cause of the weight loss is the reason for poorer outcomes, rather than the actual weight loss? Why do some people lose weight and others don’t. Have lewy bodies in the gut been investigated as a possible cause of weight loss? I fail to see how gaining weight lost due to Parkinson’s Disease can improve outcomes.

  2. Mark Turley says:

    I lost 18 pounds this year while changing diet only minimally. strange. now it appears pd may have been involved. leg and arm muscles lost a lot. my gym rat son is helping me.

  3. Anna1060 says:

    I’m 81, female, with mild symptoms that were confirmed after a DaT scan. I went from 137 lbs to 122 lbs within ten months of the diagnosis. I didn’t even notice the drop until it was time to get into cold weather clothes. Off to a nutritionist and now, 20 months into Parkinson’s, I’ve stabilized at 130, thanks to butter, cream cheese, chocolate, and bigger helpings of almost everything else. Only time will tell whether my weight loss was a combination of Dx aftershock and normal aging, or whether I’ve drawn a bad card that no amount of gorging will correct.

  4. Penny H says:

    My spouse who is female lost incredible amount of weight in just 2 years after being diagnosed with PD. It was muscle mass more than fat because she wasn’t fat to begin with. Doctors did many tests but found nothing that would cause this loss, except PD. She is physically active and swims. Her muscles are more developed but still skin hangs on her. She is 6’1” and was about 185 pounds. Now she is 145. She looks terrible and I am concerned. She eats ok but not enough to offset her weight loss and activity.

  5. Elizabeth Williams says:

    My husband has had Parkinson’s for 10 years, he is taking Eligard injection for prostate cancer. In April he weighed 155lb and now he is 145. Should I be concerned? Could it be the Eligard?

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