How Does Parkinson’s Disease Affect the Brain?


Parkinson’s disease is a progressive neurological disease where, over time, dopamine in the brain is lost, leading to problems with controlling movement. In this simple animated video from Soton Brain Hub, learn more about the pathophysiology of Parkinson’s disease and how it affects the brain.

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MORE: Parkinson’s disease symptoms: What is “freezing”?

The film explains the different parts of the brain involved in the development of the disease including the direct and indirect pathways and how this affect patients and leads to decreased motor output and some of the classic symptoms of Parkinson’s disease such as slowed movement, tremors, and rigidity. The simple diagrams illustrate excitatory and inhibitory pathways in the brain which control movement in patients with the condition.

MORE: Eleven facts about Parkinson’s disease you may not know.

Parkinson’s News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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  1. Carolyn Kelly says:

    Do you have videos on Progressive Supranuclear Palsy?

    I was diagnosed with Atypical P D approx 31/2 years ago but now my Neurologist says that she thinks that I have PSP.
    This as distressed me greatly and I am finding it difficult to find anything much about it except the diagnosis to death lifespan of 7 years.
    I would be greatful for any help you can give me.
    Thank you.
    Carolyn Kellly

  2. Helen Kirkland says:

    Hello, Thank you for the video about Parkinson Disease.

    Could you please explain Parkinsonism and the difference between that and Parkinsons as in what to expect in symptoms to tell the difference.
    Doctors told me that I had Parkinsonism as a result of two drugs interacting and causing side effects. Although my large involuntary movements decreased sometime later after stopping the first medication (stemetil), they did not cease.

    Well over a year passed with the problems persisting. Therefore, I gradually stopped taking the second medication (Seroquel) over two months and have now been off it for a couple of weeks. I still have the tremors and doing things such as writing and drawing is difficult.

    I would like to know how long these symptoms will persist. My balance and bowels have not been good either and some people wonder if I actually have Parkinson’s not Parkinsonism. I hope this is not a permanent condition but what can I do about it. Sometimes the tremors seem to be settling and other times that’s not the case – so I have times when it seems almost gone, then I try to hand-write. Not my usual standard. It just goes in jerks and gets wobbly. I don’t think the doctors think it’s bad enough to worry about. But my family and I are concerned.
    I have calligraphy and cake decorating to do for my daughter’s wedding and I only have 2 months to get control.

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