Which Parkinson’s disease treatment is most effective?

Levodopa and its derivatives are generally the most effective treatment for controlling the motor symptoms of Parkinson’s, though these medicines typically become less effective as the disease progresses. Their long-term use also can cause unpleasant side effects such as dyskinesia (uncontrolled movements). Other medications such as dopamine agonists or MAO-B inhibitors usually aren’t as effective for easing motor symptoms, but may be used on their own or in combination with levodopa to attain optimal symptom management with minimal side effects.